新疆70例艾滋病相关卡波西肉瘤治疗效果及预后分析

发布时间：2018-05-29 20:12

本文选题：艾滋病 + 卡波西肉瘤　；参考：《新疆医科大学》2014年硕士论文

【摘要】：目的：分析新疆艾滋病（AIDS）相关卡波西肉瘤（KS）患者的临床特征，探讨CD4+T淋巴细胞计数、高效联合抗反转录病毒治疗（HAART）及系统性化疗等对患者预后的影响。方法：采用回顾性研究的方法，收集2008年1月至2013年6月新疆维吾尔自治区第六人民医院收治的70例艾滋病相关卡波西肉瘤（AIDS-KS）患者的临床资料，从人群特点、病变部位及范围、KS进展情况、CD4+T淋巴细胞计数、合并机会性感染、治疗及预后等方面进行总结分析，并按照治疗方法不同分为5组：HAART组（A组）、HAART+化疗组（B1组）、化疗+HAART组（B2组）、化疗组（C组）、观察组（D组），比较不同治疗组的疗效及预后。结果：70例中维吾尔族66例（94.29%），平均年龄（39.7±10.4）岁，，男女比例2.5：1。基线CD4+T淋巴细胞计数中位数M为152.5个/μl，四分位数间距Q为231.2个/μl。A组及B1组治疗后CD4+T淋巴细胞计数增加，P值分别为0.003和0.007，差异有统计学意义； C组及D组治疗后CD4+T淋巴细胞计数下降，P值分别为0.045和0.028，差异有统计学意义。5组中D组病死率最高（22.2%）。A组45.5%出现卡波西肉瘤相关免疫重建炎性反应综合症（KS-IRIS），该组2例死亡原因均与KS-IRIS有关。结论:新疆艾滋病相关卡波西肉瘤多发生于中青年，以维吾尔族男性多见，病灶部位多样化，部分呈快速进展。B1组采取先开始高效联合抗反转录病毒治疗续以系统性化疗的治疗方法，降低了卡波西肉瘤相关免疫重建炎性反应综合症的发生率，明显改善患者预后，疗效较好。
[Abstract]:Objective: to analyze the clinical features of patients with KPS associated with AIDS in Xinjiang, and to explore the effect of CD4 T lymphocyte count, highly effective antiretrovirus therapy and systemic chemotherapy on the prognosis of the patients. Methods: from January 2008 to June 2013, 70 AIDS-KS patients with AIDS-KS were collected from the sixth people's Hospital of Xinjiang Uygur Autonomous region. The location and extent of KS, CD4 T lymphocyte count, combined with opportunistic infection, treatment and prognosis were summarized and analyzed. They were divided into 5 groups according to different treatment methods: group A, group B 1, group HAART, group B 2, group C, observation group D, the curative effect and prognosis of different treatment groups were compared. Results among 70 cases, 66 cases of Uygur nationality had an average age of 39.7 卤10.4 years, and the ratio of male to female was 2.5: 1. The median CD4 T lymphocyte count M was 152.5 / 渭 l, the quartile interval Q was 231.2 / 渭 l.A group and B1 group after treatment, the increase of CD4 T lymphocyte count was 0.003 and 0.007 respectively, there was significant difference between C group and D group. The decrease of T lymphocyte count in CD4 group was 0.045 and 0.028, respectively. The difference was statistically significant. The mortality of group D was the highest (22. 2%). Group A (45. 5%) had KS-IRIS-associated sarcoma-associated inflammatory response syndrome (KS-IRISS). The causes of death in this group were all related to KS-IRIS. Conclusion: AIDS-related Kaposi sarcoma mostly occurs in young and middle-aged people, most of them in Uygur nationality, and the foci are diverse. Partial rapid progress. Group B1 was treated with high efficiency and antiretrovirus therapy followed by systemic chemotherapy, which reduced the incidence of Kaposi sarcoma-associated immunoreconstructive inflammatory response syndrome and significantly improved the prognosis of the patients. The curative effect is better.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R512.91

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