联合抗病毒治疗乙肝肝硬化患者纤维化五项指标的临床分析
发布时间:2018-07-25 07:33
【摘要】:目的探讨联合抗病毒治疗对乙型肝炎肝硬化患者肝纤维化五项指标的影响,为临床抗病毒治疗的疗效提供参考。方法选择确诊的乙肝肝硬化患者60例,分为对照组和观察组,每组各30例。对照组患者在综合对症、支持和保肝治疗基础上给予口服抗病毒药物拉米夫定100 mg/d,1次/d;观察组患者在对照组的治疗基础上给予口服阿德福韦酯10 mg/d,1次/d。治疗期为48周,分别于试验开始前、第6、12、24、36周和48周抽取患者外周血对肝功能及层粘连蛋白、Ⅲ型前胶原、Ⅳ型胶原、透明质酸酶和脯肽酶等反映肝纤维化的五项指标进行动态观察。结果观察组患者治疗有效率为76.7%,明显高于对照组。2组患者在治疗前后AST、ALT、A/G和TBIL水平随着用药时间的延长而均有所降低,且治疗第36周和48周时组间比较差异有统计学意义(P0.05)。2组患者在治疗前后LA、HA、IV-C、PCⅢ和PLD水平随着用药时间的延长而均有所降低。对照组患者在用药第36周LA、HA、IV-C、PCⅢ和PLD与用药前相比较明显降低(P0.05)。观察组患者上述各项指标在第12周时与用药前相比较均已出现明显的降低,且差异有统计学意义;且在第24周时,2组间LA、HA、PCⅢ和PLD含量比较差异有统计学意义(P0.05)。结论拉米夫定联合阿德福韦酯抗病毒治疗可有效降低乙肝肝硬化患者肝纤维化指标的水平,起到缓解肝硬化进程的作用。
[Abstract]:Objective to investigate the effect of combined antiviral therapy on liver fibrosis in patients with hepatitis B cirrhosis. Methods 60 patients with hepatitis B cirrhosis were divided into control group and observation group with 30 cases in each group. Patients in the control group were treated with oral antiviral drug lamivudine 100 mg / d once a day on the basis of comprehensive treatment support and liver protection while patients in the observation group were given oral adefovir 10 mg / d per day on the basis of treatment in the control group. The treatment period was 48 weeks. The peripheral blood was collected from the patients with liver function and laminin, type 鈪,
本文编号:2143091
[Abstract]:Objective to investigate the effect of combined antiviral therapy on liver fibrosis in patients with hepatitis B cirrhosis. Methods 60 patients with hepatitis B cirrhosis were divided into control group and observation group with 30 cases in each group. Patients in the control group were treated with oral antiviral drug lamivudine 100 mg / d once a day on the basis of comprehensive treatment support and liver protection while patients in the observation group were given oral adefovir 10 mg / d per day on the basis of treatment in the control group. The treatment period was 48 weeks. The peripheral blood was collected from the patients with liver function and laminin, type 鈪,
本文编号:2143091
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