新疆和田地区新近诊断HIV-1人群耐药传播及亚型分布情况调查

发布时间：2018-10-22 11:25

【摘要】：目的了解新疆和田地区未治疗的HIV-1新诊断人群耐药传播情况及亚型分布。方法对新疆和田地区2013~2014年新诊断HIV-1感染人群随机抽样,对样本HIV-1 POL区进行亚型及耐药基因型分析,并评估新诊断人群HIV-1耐药传播水平。结果共有203个样本获得有效序列,样本中07_BC重组亚型193人,比例最大,占95.07%;C亚型5人,占2.46%;01_AE/B亚型2人,08_BC亚型3人;对HIV-1 POL区耐药基因突变位点进行分析,PR区耐药传播率为0.99%;RT区耐药传播率为2.46%。HIV-1耐药总传播率低于5%。结论新疆和田地区HIV-1新诊断人群的亚型主要是以07_BC重组亚型为主;和田地区未经抗病毒治疗新诊断HIV-I感染者中已经出现PR和RT区耐药突变株,但传播水平尚处于低流行状态,应适时开展耐药性监测。
[Abstract]:Objective to investigate the distribution of drug resistance and its subtypes in untreated HIV-1 patients in Hotan, Xinjiang. Methods A random sample of newly diagnosed HIV-1 infections from 2013 to 2014 in Hotan, Xinjiang, was used to analyze the subtypes and drug resistant genotypes in the HIV-1 POL region, and to evaluate the transmission level of HIV-1 resistance in the newly diagnosed population. Results A total of 203 samples were obtained, of which 193 were 07_BC recombinant subtype (95.07%), 5 were subtype C (2.46 / 01A / B subtype 2, 3 were 08_BC subtype). The mutation site of drug resistance gene in HIV-1 POL region was analyzed. The drug resistance transmission rate of PR region was 0.99. The total drug resistance transmission rate of 2.46%.HIV-1 region was lower than that of 2.46%.HIV-1 region and that of RT region was lower than that of 2.46%.HIV-1 region. Conclusion the main subtypes of HIV-1 newly diagnosed population in Hotan area of Xinjiang are 07_BC recombinant subtypes, PR and RT resistant mutants have been found in newly diagnosed HIV-I infected persons without antiviral treatment in Hotan area, but the transmission level is still low. Drug resistance monitoring should be carried out in due course.
【作者单位】：新疆和田地区疾病预防控制中心;安徽省疾病预防控制中心;
【基金】：新疆维吾尔自治区自然科学基金(编号:201442137-05)
【分类号】：R512.91

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