银川市孕妇及小月龄婴儿麻疹抗体水平调查

发布时间：2018-11-02 20:52

【摘要】：目的掌握银川市孕妇和小月龄(0~7月)婴儿麻疹抗体水平,为制定麻疹免疫策略和防控措施提供科学依据。方法在全市各县、市、区中选取6个调查点(社区卫生服务站和乡镇卫生院);每个调查点各月龄随机收集2人,每个县区完成调查84人,全市共调查504人;在全市各县、市、区医院产科收集待分娩产妇及新生儿20对,每个县区完成调查20对,全市共调查120对;共计调查744人,采集血标本,检测麻疹IgG抗体,同时对被调查者进行问卷调查,分析麻疹抗体水平状况。结果 (1)120名健康孕妇麻疹IgG抗体阳性率为71.67%,孕妇抗体几何平均浓度(GMC)为263.81 mIU/ml。孕妇各年龄组之间抗体阳性率差异有统计学意义(χ~2=6.062,P=0.048)。(2)0~7月龄婴儿麻疹Ig G抗体阳性率分别为76.67%、51.43%、40.00%、27.78%、20.00%、19.72%、18.92%、14.93%。不同地区(χ~2=55.160,P0.05)、不同民族(χ~2=6.930,P=0.031)、不同月龄(χ~2=132.921,P0.001)、不同分娩方式(χ~2=24.250,P0.001)的婴儿之间麻疹抗体阳性率差异有统计学意义。结论银川市孕妇及小月龄婴儿麻疹抗体水平整体较低,建议必要时对育龄期妇女进行婚前MV复种和研制适用于小月龄婴儿接种的新型疫苗,以降低婴儿的麻疹发病率。
[Abstract]:Objective to understand the level of measles antibody among pregnant women and infants of young month (0 ~ 7 months) in Yinchuan city, and to provide scientific basis for making measles immunization strategy and prevention and control measures. Methods six investigation sites (community health service station and township health center) were selected in every county, city and district in the whole city, 2 people were collected randomly at each survey point, 84 people were completed in each county and district, and 504 people were investigated in the whole city. In every county, city, district hospital and obstetrics department, 20 pairs of parturient and newborn were collected, 20 pairs were completed in each county and district, and 120 pairs were investigated in the whole city. A total of 744 people were investigated, blood samples were collected, measles IgG antibody was detected, and the survey was carried out to analyze the status of measles antibody level. Results (1) the positive rate of measles IgG antibody in 120 healthy pregnant women was 71.67 and the geometric mean concentration of (GMC) was 263.81 mIU/ml.. There was significant difference in the positive rate of Ig G antibody among different age groups of pregnant women (蠂 ~ 2 ~ (6.062P) 0.048). (_ 2). The positive rate of Ig G antibody in 7-month-old infants was 76.67 and 51.430.000 respectively. 19.72 and 18.92 about 14.93. Different regions (蠂 ~ 2 ~ 2 ~ 2), different nationalities (蠂 ~ 2 ~ 2 ~ 2 ~ (6.930), different months (蠂 ~ 2 ~ 2 ~ 2 ~ 2 ~ 2 ~ (2) 2.921 ~ (1) P ~ (0.001), different delivery modes (蠂 ~ (2) ~ 2 ~ (24.250), There was significant difference in the positive rate of measles antibody among infants (P 0.001). Conclusion the level of measles antibody of pregnant women and infants in Yinchuan city is lower. It is suggested that MV should be re-inoculated before marriage and a new vaccine should be developed in order to reduce the incidence of measles in infants.
【作者单位】：银川市卫生和计划生育委员会;宁夏医科大学;宁夏医科大学总医院;银川市疾病预防控制中心;
【基金】：2015宁夏自然科学基金资助(项目编号:NZ15236)
【分类号】：R186;R511.1

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