寨卡病毒与登革热病毒交叉反应抗体引发严重性疾病的关系
发布时间：2018-11-18 17:23
【摘要】：登革病毒(DENV)不同血清型感染后,易导致抗体依赖增强反应(ADE)的严重性疾病发生。2015年5月巴西流行寨卡病毒(ZIKV)后,截止至2016年11月,流行已扩散到60多个国家和地区,毗邻我国的一些东南亚国家也有报告ZIKV感染病例。近期有研究显示,ZIKV和DENV的包膜(E)蛋白EDI和EDII两表位引发的抗体或由此产生的单克隆抗体具有很强的交叉反应性,易引起ADE的发生。我国沿海省份历年时有DENV病毒流行,今后ZIKV流行事件极有可能发生,因此,由该病毒流行引起的严重性疾病发生我们必须要关注和提出应对措施。
[Abstract]:Infection with different serotypes of dengue virus (DENV) can easily lead to serious diseases that rely on an enhanced antibody response to (ADE). After the May 2015 epidemic of Zika virus (ZIKV) in Brazil, as of November 2016, The epidemic has spread to more than 60 countries and regions, and some Southeast Asian countries adjacent to China have also reported cases of ZIKV infection. Recent studies have shown that the antibodies induced by the EDI and EDII epitopes of (E) protein of ZIKV and DENV, or the monoclonal antibodies produced therefrom, have strong cross-reactivity and are prone to the occurrence of ADE. DENV virus has been prevalent in coastal provinces of China over the years, and it is very likely that ZIKV epidemic events will occur in the future. Therefore, we must pay attention to the occurrence of serious diseases caused by the epidemic of the virus and put forward some countermeasures.
【作者单位】： 福建省疾病预防控制中心;福建医科大学公共卫生学院;福建省人兽共患病重点实验室;
【基金】：国家高技术研究发展计划(No.2011AA02A114)资助~~
【分类号】：R511;R512.8
，
本文编号：2340651
[Abstract]:Infection with different serotypes of dengue virus (DENV) can easily lead to serious diseases that rely on an enhanced antibody response to (ADE). After the May 2015 epidemic of Zika virus (ZIKV) in Brazil, as of November 2016, The epidemic has spread to more than 60 countries and regions, and some Southeast Asian countries adjacent to China have also reported cases of ZIKV infection. Recent studies have shown that the antibodies induced by the EDI and EDII epitopes of (E) protein of ZIKV and DENV, or the monoclonal antibodies produced therefrom, have strong cross-reactivity and are prone to the occurrence of ADE. DENV virus has been prevalent in coastal provinces of China over the years, and it is very likely that ZIKV epidemic events will occur in the future. Therefore, we must pay attention to the occurrence of serious diseases caused by the epidemic of the virus and put forward some countermeasures.
【作者单位】： 福建省疾病预防控制中心;福建医科大学公共卫生学院;福建省人兽共患病重点实验室;
【基金】：国家高技术研究发展计划(No.2011AA02A114)资助~~
【分类号】：R511;R512.8
，
本文编号：2340651
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