IL-12A、IL-1B、IL-17A单核苷酸多态性与慢性乙型肝炎恩替卡韦治疗HBeAg血清学转换的遗传关联研究

发布时间：2018-12-23 20:56

【摘要】：目的通过遗传关联研究观察慢性HBV感染免疫相关重要细胞因子IL-12、IL-1B、IL-17的基因多态性与恩替卡韦抗病毒治疗HBe Ag血清学转换之间的关联。方法对109例恩替卡韦抗病毒治疗的HBe Ag阳性慢性乙型肝炎患者每3个月进行肝功能、乙肝标志物、HBV DNA检测,进行HBe Ag血清学转换评估,治疗24个月时的应答情况作为判定应答与否的标准。发生HBe Ag血清学转换者为应答组;未发生HBe Ag血清学转换者为无应答组;分析IL-12A rs568408、IL-1B rs1143623、IL-17A rs8193036基因型与HBe Ag血清学转换之间的关联。结果 29例获得HBe Ag血清学转换(应答组),80例未获得HBe Ag血清学转换(无应答组),总体应答率26.6%。IL-12A rs568408与HBe Ag血清学转换显著相关,GA基因型发生HBe Ag血清转换的易感性显著高于GG基因型[OR=3.72(1.34~10.32),P=0.012]。未发现IL-1B rs1143623[OR=1.99(0.72~5.44),P=0.17]和IL-17A rs8193036[OR=1.54(0.32~7.33),P=0.60]与HBe Ag血清学转换存在关联。结论 IL-12A rs568408与慢性乙型肝炎恩替卡韦治疗HBe Ag血清学转换存在关联。
[Abstract]:Objective to investigate the association between gene polymorphisms of immune-related cytokines IL-12,IL-1B,IL-17 and entecavir antiviral therapy for HBe Ag serological transformation in chronic HBV infection. Methods 109 patients with HBe Ag positive chronic hepatitis B treated with entecavir antiviral therapy were examined for liver function, hepatitis B marker, HBV DNA and HBe Ag serological conversion every 3 months. Responses at 24 months of treatment were used as criteria for determining responses. The patients with HBe Ag seroconversion were in response group and those without HBe Ag serological conversion were non-responders. The association between IL-12A rs568408,IL-1B rs1143623,IL-17A rs8193036 genotype and HBe Ag serological transformation was analyzed. Results HBe Ag serological conversion was obtained in 29 cases and HBe Ag serological conversion in 80 cases. The total response rate (26.6%.IL-12A rs568408) was significantly correlated with HBe Ag serological conversion. The susceptibility to HBe Ag seroconversion in GA genotype was significantly higher than that in GG genotype [OR=3.72 (1.3410. 32), P0. 012]. There was no association between IL-1B rs1143623 [OR=1.99 (0.72 ~ 5.44), P _ (0.17)] and IL-17A rs8193036 [OR=1.54 (0.32 ~ 7.33), P _ (0. 60)] and serological transformation of HBe Ag. Conclusion IL-12A rs568408 is associated with HBe Ag serological conversion in patients with chronic hepatitis B treated with entecavir.
【作者单位】：第三军医大学西南医院全军感染病研究所感染病研究重庆市重点实验室;解放军第88医院全军肝病诊治中心;
【基金】：国家自然科学基金面上项目(81270563)~~
【分类号】：R512.62

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