HIV-1 Vpr protein activates the NF-κB pathway to promote G2/

发布时间：2021-01-11 08:05

　　Viral protein R（Vpr） plays an important role in the replication and pathogenesis of Human immunodeficiency virus type 1（HIV-1）. Some of the various functions attributed to Vpr, including the induction of G2/M cell cycle arrest, activating the NF-κB pathway, and promoting viral reverse transcription, might be interrelated. To test this hypothesis, a panel of Vpr mutants were investigated for their ability to induce G2/M arrest and to activate the NF-κB pathway. The results showed that the Vpr mut... 

【文章来源】：Virologica Sinica. 2015,30(06)

【文章页数】：8 页

【文章目录】：
INTRODUCTION
MATERIALS AND METHODS
    Plasmids
    Cell culture and transfection
    RNA interference
    Cell cycle analysis
    Luciferase assay
RESULTS
    NF-κB activation and G2/M arrest induced by Vpr mutants
    Activation of the NF-κB pathway promotes Vprinduced cell cycle arrest
DISCUSSION
COMPLIANCE WITH ETHICS GUIDELINES
AUTHOR CONTRIBUTIONS



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