硒化修饰太子参多糖对免疫损伤小鼠的免疫保护作用

发布时间：2018-02-21 11:48

本文关键词： 硒化太子参多糖环磷酰胺免疫损伤免疫保护　出处：《中国兽医学报》2017年11期 　论文类型：期刊论文

【摘要】：取220只小鼠随机分为11组,即健康对照组、给药组(9个组)和环磷酰胺(CY)模型组,每组20只。其中,给药组的9个组中,硒化太子参多糖2(sRPP2)、硒化太子参多糖3(sRPP3)和太子参多糖(RPP)各按质量浓度1,2,3g/L分别设3个组。健康对照组和环磷酰胺(CY)模型组皮下注射生理盐水,持续14d。给药组皮下注射给药,连续14d。15d开始,除了健康对照组,9个给药组和环磷酰胺(CY)模型组腹腔注射环磷酰胺,连续注射3d,分别测定免疫器官指数、免疫球蛋白IgM和IgG的含量、巨噬细胞分泌细胞因子TNF-α和IL-6含量、免疫细胞吞噬指数。结果显示:sRPP2、sRPP3、RPP各项指标都高于环磷酰胺组(P0.05)。结果表明:硒化修饰能增强太子参多糖对免疫损伤小鼠的免疫保护作用,sRPP3的作用最好。
[Abstract]:220 mice were randomly divided into 11 groups: healthy control group (n = 20), control group (n = 9) and cyclophosphamide CYL model group (n = 20). The polysaccharides of Pseudostellariostellariostellariostellariostellariostellariostellariae selenosum 2s RPP2P) and Pseudostellariostellaria Polysaccharide RPP3 (RPP3) were divided into 3 groups according to their mass concentration: healthy control group and cyclophosphamide CYL model group were subcutaneously injected with normal saline for 14 days, and the control group was subcutaneously injected with normal saline for 14 days, and the control group was subcutaneously injected with normal saline for 14 days. In addition to the healthy control group, nine administration groups and Cyclophosphamide model group were intraperitoneally injected with cyclophosphamide for 3 days. The immune organ index, the content of immunoglobulin IgM and IgG were measured respectively. Macrophages secrete cytokines TNF- 伪 and IL-6, The phagocytic index of immune cells. The results showed that each index of RPP was higher than that of cyclophosphamide group (P 0.05). The results showed that selenium modification could enhance the protective effect of Pseudostellaria heterophylla polysaccharides on immune injury mice.
【作者单位】：福建农林大学兽医中药与动物保健福建省重点实验室;
【基金】：福建省教育厅项目(JA14111) 福建农林大学动物科学学院青年教师种子基金项目
【分类号】：S852.4

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