四川省猪、鸡源大肠杆菌对抗生素耐药性研究

发布时间：2018-08-17 17:56

【摘要】：对四川省2009-2014年共2 954株猪、鸡源大肠杆菌进行13种抗生素耐药性测定,同时对耐头孢噻呋大肠杆菌及O157菌株耐药基因进行检测。结果表明:大肠杆菌对抗生素耐药谱广,多重耐药严重。大肠杆菌对抗生素耐药率呈逐年波动下降趋势,猪源大肠杆菌对抗生素耐药率总体耐药率为40.40%~92.32%,抗生素耐药率依次为:TET(92.32%)SIZ(91.96%)AMP(91.25%)SXT(87.56%)DO(77.67%)FFC(73.97%)SH(69.91%)EN(66.00%)AMC(61.10%)OFX(59.39%)CN(57.82%)PME(42.53%)CEF(40.40%)。鸡源大肠杆菌对抗生素的总体耐药率为9.17%-89.41%,抗生素耐药率依次为:SIZ(89.41%)AMP(85.01%)SXT(83.40%)TET(83.01%)EN(72.03%)OFX(63.37%)AMC(62.14%)DO(58.90%)FFC(55.10%)SH(50.52%)CEF(46.9%)CN(33.91%)PME(9.17%)。2009年-2014年猪源大肠杆菌耐药率总体高于鸡源大肠杆菌。研究表明,监测大肠杆菌的抗生素耐药性对动物的养殖、疾病的预防及耐药性的控制有着重要意义。
[Abstract]:A total of 2 954 strains of swine and chicken Escherichia coli from Sichuan Province from 2009 to 2014 were tested for drug resistance of 13 antibiotics, and the resistant genes of cefotaxime Escherichia coli and strain O157 were also detected. The results showed that Escherichia coli had a wide spectrum of antibiotic resistance and severe multi-drug resistance. The resistance rate of Escherichia coli to antibiotics decreased year by year. The overall resistance rate of porcine Escherichia coli to antibiotics was 40.400.40% and 92.32% respectively. The antibiotic resistance rate was in turn: Tet (92.32%) SIZ (91.96%) AMP (91.25%) DO (77.67%) FFC (73.97%) SH (69.91%) EN (66.00%) AMC (61.10%) OFX (59.39%) CN (57.82%) PME (42.53%) CEF (40.40%). The overall resistance rate of chicken Escherichia coli to antibiotics was 9.17- 89.41, and the antibiotic resistance rate was: SIZ (89.41%) AMP (85.01%) SXT (83.40%) TET (83.01%) EN (73.37%) OFX (62.37%) AMC (62.14%) DO (58.90%) FFC (55.10%) SH (50.52%) CEF (46.9%) CN (33.91%) PME (9.17%). The results show that monitoring antibiotic resistance of Escherichia coli plays an important role in animal breeding, disease prevention and drug resistance control.
【作者单位】：四川省兽药监察所;中国兽医药品监察所;四川农业大学;
【基金】：农业部“948项目”(2011-G14) 教育部“长江学者和创新团队发展计划”(IRT13083) 国家自然科学基金(31400066)
【分类号】：S852.61

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