“百病无忧膏”的药效学研究

发布时间：2018-10-25 06:49

【摘要】：目的:中药既能防治各种动物的疾病,还能在动物的个体发育中促进动物的生长,还可完善饲草料营养性。近年来,人们对中草药的研究越来越多,其药理作用受到人们广泛关注。本研究对“百病无忧膏”的药效学进行了研究,为今后“百病无忧膏”在兽医临床的开发应用提供理论依据。方法:通过建立二甲苯致小鼠耳壳肿胀模型、醋酸腹腔注射致小鼠疼痛模型、家兔骨折模型,观察了“百病无忧膏”的抗炎、镇痛、促进骨折愈合作用效果。结果:(1)统计学分析表明,阿司匹林组和“百病无忧膏”组均与空白组差异显著(P0.05),而阿司匹林与“百病无忧膏”之间差异不显著(P0.05),说明“百病无忧膏”具有明显的抗炎作用;(2)小鼠腹腔注醋酸,“百病无忧膏”组的镇痛率为100%(8/8),阿司匹林组的镇痛率为75%(6/8);(3)X线和组织切片观察都表明给药组骨折愈合情况好于空白组,且骨折愈合情况良好。结论:“百病无忧膏”具有抗炎、镇痛、促进骨折愈合的作用。
[Abstract]:Objective: Chinese medicine not only can prevent and cure various animal diseases, but also can promote the growth of animals during their ontogeny. In recent years, more and more researches have been made on Chinese herbal medicine, and its pharmacological effect has been paid more and more attention. In this study, the pharmacodynamics of "hundred diseases without worry ointment" was studied, which provided the theoretical basis for the development and application of "hundred diseases without worry ointment" in veterinary clinic. Methods: by establishing the mouse ear shell swelling model induced by xylene, the mice pain model induced by acetic acid intraperitoneal injection, and the rabbit fracture model, the anti-inflammatory and analgesic effects of "Baijiangshuisui" were observed, and the effect of promoting fracture healing was observed. Results: (1) Statistical analysis showed that, The aspirin group and the "hundred disease free worry" group were significantly different from the blank group (P0.05), but there was no significant difference between the aspirin and the "hundred disease free worry" group (P0.05), which indicated that the "hundred disease free worry ointment" had obvious anti-inflammatory effect; (2) the mice were injected acetic acid intraperitoneally. The analgesic rate was 100% (8 / 8) and 75% (6 / 8); (_ 3) in the "Baijiangrui" group and 75% (6 / 8); (_ 3) in the aspirin group. The results showed that the fracture healing was better in the treatment group than in the blank group, and the fracture healing was good. Conclusion: 100 disease free-care ointment has the function of anti-inflammation, analgesia and promoting fracture healing.
【学位授予单位】：西北农林科技大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：S853.7

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