原儿茶酸对帕金森模型大鼠血清TNF-α、IL-1β及氧化应激产物水平的影响

发布时间：2017-12-31 03:10

本文关键词：原儿茶酸对帕金森模型大鼠血清TNF-α、IL-1β及氧化应激产物水平的影响　出处：《中国生化药物杂志》2015年11期 　论文类型：期刊论文

【摘要】：目的探讨原儿茶酸对帕金森模型大鼠血清肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白介素1β(interleukin-1β,IL-1β)及氧化应激产物水平的影响。方法选取雄性SD大鼠60只,随机分为正常对照组(n=10)、模型组(n=10)、美多芭组(n=20)和原儿茶酸组(n=20)。模型组、美多芭组和原儿茶酸组建立帕金森大鼠模型,美多芭组和原儿茶酸组大鼠分别给予相应药物治疗,持续2周。治疗结束后,对所有大鼠的血清TNF-α、丙二醛(malondialdehyde,MDA)、超氧化物歧化酶(superoxide dismutase,SOD)及IL-1β水平进行检测。结果与正常对照组比较,模型组血清TNF-α、IL-1β、MDA水平明显升高,而SOD水平明显降低(P0.05)。与模型组比较,经治疗后美多芭组和原儿茶酸组血清TNF-α、IL-1β、MDA水平明显降低,而SOD水平明显升高(P0.05)。美多芭组与原儿茶酸组血清TNF-α、IL-1β、MDA及SOD比较差异无统计学意义。结论原儿茶酸能够明显降低帕金森模型大鼠血清TNF-α、MDA及IL-1β水平,提高SOD活性,对帕金森病引起的氧化应激损伤有保护作用。
[Abstract]:Objective to investigate the effect of protocatechuic acid on serum tumor necrosis factor- 伪 (TNF- 伪) of Parkinson's model rats. Methods 60 male Sprague-Dawley rats were randomly divided into normal control group (n = 10). Model group, Medoba group and protocatechuic acid group respectively. Model group, medoba group and protocatechuic acid group were used to establish Parkinson's rat model. The rats in the medoba group and protocatechuic acid group were treated with corresponding drugs for 2 weeks respectively. After the treatment, the serum TNF- 伪 and malondialdehyde were obtained from all the rats. The levels of MDAA, superoxide dismutase (SOD) and IL-1 尾 were measured. In the model group, the serum TNF- 伪 -IL-1 尾 -malondialdehyde (MDA) level was significantly increased, while the SOD level was significantly decreased (P 0.05), compared with the model group. After treatment, the levels of MDA in serum TNF- 伪 and IL-1 尾 in Madopa group and protocatechuic acid group were significantly decreased. However, the level of SOD increased significantly (P 0.05). The serum levels of TNF- 伪 and IL-1 尾 in the medoba group and protocatechuic acid group were significantly higher than those in the control group. Conclusion Protocatechuic acid can significantly decrease the levels of serum TNF- 伪 and IL-1 尾 and increase the activity of SOD in Parkinson's model rats. It has protective effect on oxidative stress injury caused by Parkinson's disease.
【作者单位】：徐州医学院基础医学院遗传学教研室;
【基金】：徐州医学院优秀人才科研启动基金(D2014004)
【分类号】：R965;R-332
【正文快照】： 帕金森病(Parkinson's disease,PD)又称“震颤麻痹”、巴金森症或柏金逊症[1],是常见的神经系统变性疾病,以中脑黑质多巴胺能神经元的变性死亡,引起纹状体多巴胺含量下降为主要的病理改变。容易引起肢体静止性震颤、肌强直、运动迟缓、姿势步态障碍等表现。PD好发于老年人,有

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