代谢、血液碱化和纯氧影响呼吸调控的人体实验研究Ⅰ:运动试验

发布时间：2018-01-01 06:37

本文关键词：代谢、血液碱化和纯氧影响呼吸调控的人体实验研究Ⅰ:运动试验　出处：《中国应用生理学杂志》2015年04期 　论文类型：期刊论文

【摘要】：目的:在整体整合生理学医学理论的指导下,通过分析正常人运动期间心肺代谢等多系统功能整体整合的连续动态变化,探讨正常环境运动状态下呼吸反应模式的调控机理。方法:选正常志愿者5名,在美国洛杉矶加州大学Harbor-UCLA医学中心分别进行动脉置管,在常温室内空气状态下完成症状限制性最大极限心肺运动试验(CPET)。在运动过程中,连续测定肺通气指标及每分钟动脉取样的血气分析指标的变化,对CPET期间呼吸气体交换和血气指标的动态变化进行统计分析。结果:在CPET期间,随着运动功率逐步递增,分钟摄氧量(每呼吸摄氧量×呼吸频率=每搏摄氧量×心率)和分钟通气量(潮气量×呼吸频率)均呈现近于线性渐进性递增(与静息状态比较,P0.05~0.001);在运动超过无氧阈和呼吸代偿点后,分钟通气量的上升反应更加显著。结论:人体在运动过程中,为了克服自行车功率计的阻力而发生代谢率改变,呼吸随代谢改变而变化,高强度运动时酸性代谢产物堆积更加加剧呼吸反应。
[Abstract]:Objective: under the guidance of integrative physiology medicine theory, the continuous dynamic changes of the whole integration of multi-system function such as cardiopulmonary metabolism during exercise in normal people were analyzed. Methods: 5 normal volunteers were selected to carry out arterial catheterization at Harbor-UCLA Medical Center, University of California, Los Angeles, USA. During exercise, the pulmonary ventilation index and the blood gas analysis index of arterial sampling per minute were measured continuously during the exercise. The results were as follows: (1) in the condition of indoor air at room temperature, the symptom limiting maximum limit cardiopulmonary exercise test was completed and the changes of pulmonary ventilation index and blood gas analysis index were continuously measured during exercise. The dynamic changes of respiratory gas exchange and blood gas index during CPET were statistically analyzed. Results: during CPET, the dynamic changes of respiratory gas exchange and blood gas index increased gradually with the exercise power. The minute oxygen uptake (per breath oxygen uptake 脳 respiration frequency = per beat oxygen uptake 脳 heart rate) and minute ventilation volume (tidal volume 脳 respiration rate) were increased gradually (compared with resting state). P0.05C0. 001; After exercise exceeded the anaerobic threshold and the respiratory compensation point, the increase of minute ventilation rate was more significant. Conclusion: the metabolic rate changes in order to overcome the resistance of bicycle power meter during exercise. Respiration changes with the change of metabolism, and the accumulation of acid metabolites in high intensity exercise intensifies the respiratory response.
【作者单位】：中国医学科学院北京协和医学院国家心血管病中心阜外医院心血管疾病国家重点实验室心血管病国家临床医学研究中心;河北医科大学第四人民医院功能科;美国加州大学洛杉矶分校Harbor-UCLA医学中心洛杉矶生物医学研究院圣约翰心血管研究中心;山东省潍坊医学院麻醉学系临床麻醉学教研室和临床医学系;广州市第一人民医院麻醉科;
【基金】：国家自然科学基金医学科学部面上项目(81470204) 国家高新技术研究发展计划(863计划)课题(2012AA021009) 中国医学科学院国家心血管病中心科研开发启动基金(2012-YJR02)
【分类号】：R33
【正文快照】： (1.中国医学科学院北京协和医学院国家心血管病中心阜外医院心血管疾病国家重点实验室,心血管病国家临床医学研究中心,北京100037;2.美国加州大学洛杉矶分校Harbor-UCLA医学中心,洛杉矶生物医学研究院,圣约翰心血管研究中心,美国加州90502;3.河北医科大学第四人民医院功能科,

【参考文献】