代谢综合征合并非酒精性脂肪肝炎小鼠模型的建立及银杏叶提取物治疗代谢综合征作用及其机制的探讨

发布时间：2018-01-02 09:26

本文关键词：代谢综合征合并非酒精性脂肪肝炎小鼠模型的建立及银杏叶提取物治疗代谢综合征作用及其机制的探讨　出处：《中国协和医科大学》2008年博士论文　论文类型：学位论文

【摘要】： 随着生活方式和饮食结构的改变,代谢综合征的发病率日益增高。代谢综合征是一种以肥胖、胰岛素抵抗及脂质代谢紊乱等为特征的疾病,其在肝脏的表现为非酒精性脂肪性肝病(non-alcoholic fatty liverdisease,NAFLD)。NAFLD主要包括单纯性脂肪肝、非酒精性脂肪性肝炎(non-alcoholic steatohepaitis,NASH)、以及肝硬化三个阶段,其中NASH是NAFLD发展过程中的关键阶段。对NASH的发病机制和防治措施的研究已经成为NAFLD研究的焦点。代谢综合征发病机制复杂且受多种因素调控,多需要长期的药物治疗,因此从天然产物中寻找疗效肯定、毒副作用小的预防和治疗代谢综合征的药物显得尤其重要。基于对代谢综合征的上述两方面的研究现状了解及关注,本文论文内容主要分为“代谢综合征合并非酒精性脂肪肝炎小鼠模型的建立”和“银杏叶提取物治疗代谢综合征作用及其机制的探讨”两个部分。
[Abstract]:With the way of life and the change of diet structure, the incidence of metabolic syndrome increased. Metabolic syndrome is a disease with obesity, insulin resistance and lipid metabolism disorder characterized by the liver for nonalcoholic fatty liver disease (non-alcoholic fatty liverdisease, NAFLD.NAFLD) includes simple fatty liver disease, nonalcoholic steatohepatitis (non-alcoholic steatohepaitis, NASH), and liver cirrhosis in three stages, in which NASH is the key stage in the development of NAFLD. The research of pathogenesis and prevention and control measures for NASH has become the focus of NAFLD research. The pathogenesis of metabolic syndrome is complex and regulated by a variety of factors, many need long-term drug treatment, therefore from natural products for curative effect, little side effect in the prevention and treatment of metabolic syndrome drugs are particularly important. Based on metabolic syndrome The above two aspects of understanding and attention are concerned. The contents of this paper are mainly divided into two parts: "metabolic syndrome is not the establishment of a mouse model of alcoholic steatohepatitis," and "Ginkgo biloba extract treatment of the role of metabolic syndrome and its mechanism".

【学位授予单位】：中国协和医科大学
【学位级别】：博士
【学位授予年份】：2008
【分类号】：R589;R575.5;R285.5;R-332

【引证文献】