青少年双生子体型指征相关指标遗传度研究

发布时间：2018-01-02 13:07

本文关键词：青少年双生子体型指征相关指标遗传度研究　出处：《青岛大学》2010年硕士论文　论文类型：学位论文

【摘要】： 目的用经典的双生子设计探讨遗传因素和环境因素对青少年身高、体重、体质指数(BMI)、腰围、腰臀围比值(WHR)等体型指征相关指标的影响程度。方法选择青岛地区自愿参加本研究的375对11-19岁双生子为研究对象,经过问卷调查、体格检查等获得现场流行病学资料数据库,同时对性别相同的双生子通过16个多态标记进行卵型鉴定,在此基础上,应用SPSS15.0软件及Mx软件进行数据处理,通过构建结构方程模型分析计算体型指征相关指标的遗传度。结果本次调查共收集到362对青少年双生子的身高、体重、BMI的有效数据,327对青少年双生子腰围、WHR的有效数据,对数据进行拟合处理,得出身高、腰围和WHR的最佳拟合模型ACE模型,体重和BMI的最佳拟合模型为AE模型,调整年龄性别后,估算青岛市青少年双生子身高的遗传度为66%,体重的遗传度为84%,BMI的遗传度为75%,腰围的遗传度为8%,WHR的遗传度为53%。结论在青少年双生子体型指征的相关指标中,身高、体重、BMI均受遗传因素影响较大,WHR在受遗传因素影响的同时也一定程度上受到环境因素的影响,而腰围则主要受环境影响,因此本研究提示可以通过对儿童青少年后天环境因素的改变而达到预防肥胖等疾病的发生的效果。
[Abstract]:Objective To explore the influence of genetic factors and environmental factors on the body weight , body mass index ( BMI ) , waist circumference , waist hip ratio ( WHR ) , etc . Methods 375 pairs of 11 - 19 year - old twins who volunteered to participate in the study were selected from Qingdao . The data base of site epidemiology was obtained by means of questionnaire , physical examination and so on . Results The data of height , weight and BMI of adolescent twins were collected from the survey . The best fit model of BMI was 66 % , the heritability of weight and BMI was 66 % , the heritability of body weight and BMI was 84 % , the heritability of BMI was 75 % , the heritability of waist circumference was 8 % , and the heritability of WHR was 53 % . Conclusion The height , body weight and BMI were influenced by genetic factors in the related indexes of adolescent twins . WHR was influenced by genetic factors to some extent , while the waist circumference was affected by environmental factors .

【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R394

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