缰核损毁对大鼠睡眠剥夺后松果体内褪黑素的影响

发布时间：2018-01-02 19:33

本文关键词：缰核损毁对大鼠睡眠剥夺后松果体内褪黑素的影响　出处：《吉林大学》2008年硕士论文　论文类型：学位论文

【摘要】： 为了证明缰核(Hb)参与了松果体(PG)内褪黑素(MT)水平的调节,分别损毁全Hb、内侧缰核(MHb)和外侧缰核(LHb),测量正常睡眠及睡眠剥夺情况下PG内MT含量的变化。结果:正常睡眠条件下,与对照组相比,全Hb及MHb损毁组大鼠PG中MT水平降低,LHb损毁组大鼠PG中MT水平增加;睡眠剥夺条件下,大鼠PG内MT含量明显降低,全Hb及MHb损毁组大鼠PG内MT水平与未损毁组相比无明显变化,LHb损毁组大鼠PG中MT水平增加。实验结果证明,Hb能调节PG内MT的分泌,MHb能兴奋PG内的MT分泌细胞,使MT的合成和分泌增加,LHb的作用则相反;全Hb损毁可导致机体发生睡眠剥夺样改变;在睡眠剥夺状态下LHb对PG内MT的合成及分泌的抑制作用更加突出。
[Abstract]:In order to prove that Hb in habenular nucleus was involved in the regulation of melatonin (MTB) level in PGs of pineal gland, it damaged all HB, MHb in medial habenular nucleus and LHb in lateral habenular nucleus, respectively. Results: under normal sleep condition, the MT level of PG in the whole HB and MHb damaged group was lower than that in the control group. The level of MT in PG was increased in LHb lesion group. Under the condition of sleep deprivation, the content of MT in PG of rats decreased significantly, and the MT level in PG of rats with total HB and MHb damage had no significant change compared with that of non-damaged group. The results showed that Hb could regulate the secretion of MT in PG and excite the secretion of MT in PG, and increase the synthesis and secretion of MT. The effect of LHb was opposite. Total HB damage may lead to sleep deprivation-like changes in the body; The inhibitory effect of LHb on the synthesis and secretion of MT in PG was more prominent under sleep deprivation.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2008
【分类号】：R363

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