低频交流磁诱导对记忆作用机理的研究

发布时间：2018-01-03 08:33

本文关键词：低频交流磁诱导对记忆作用机理的研究　出处：《天津大学》2009年硕士论文　论文类型：学位论文

【摘要】： 利用外界物理因子影响脑内变化进而调节人的精神活动,一直是世界医学领域中一项引人注目的研究活动。目前,经颅磁刺激技术已经越来越多的用于学习与记忆功能的研究中,许多研究表明,不同形式的磁刺激可以促进或者破坏学习记忆功能。这些结果显示经颅磁刺激技术已经成为脑认知研究的有效工具,并将更加广泛的应用于学习记忆的研究中。在深入研究经颅磁刺激对于学习记忆的影响机制后,设计实现了一套经颅磁诱导系统。以环形单线圈作为磁场耦合线圈,利用经典的ADuC845控制输出不同频率的正弦信号,信号通过TDA7294功率放大电路,驱动线圈产生磁场。该系统可产生不同频率的正弦信号,输出时间可控。本设计以正弦形式(或类正弦)周期性变化的磁场取代脉冲磁场刺激和电刺激,作用于动物脑部,观察周期性变化的磁场对动物学习记忆能力的影响。这种研究连续周期性变化磁场对大脑的影响异于以往所研究的脉冲磁场,也不同于静态恒定磁场,将是对磁场与神经相互作用新的探索。该经颅磁诱导系统功能化设计使操作简单方便。通过动物学习记忆的行为学训练和测试,表明系统对记忆的增加是有所帮助的。同时,为了更好的证明经颅磁诱导的影响,本文还对提取诱导前后的大鼠脑电进行功率谱分析,得出磁诱导能够改变脑电功率谱分布的结论。这些实验结果不仅验证了理论的合理性和可行性,也为磁诱导开辟了新的应用领域,为提高记忆提供了新的途径。
[Abstract]:The use of external physical factors to influence brain changes and thus regulate mental activities has been a noticeable research activity in the field of medicine in the world. At present. Transcranial magnetic stimulation (TMS) technology has been increasingly used in the study of learning and memory, many studies show that. Different forms of magnetic stimulation can promote or damage learning and memory function. These results show that transcranial magnetic stimulation has become an effective tool in brain cognitive research. And will be more widely used in the study of learning and memory. After deeply studying the influence mechanism of transcranial magnetic stimulation on learning and memory, a transcranial magnetic induction system is designed and implemented. The loop single coil is used as the coupling coil of magnetic field. The classical ADuC845 is used to control and output sinusoidal signals with different frequencies. The signal is driven by TDA7294 power amplifier circuit to produce magnetic field. This system can produce sinusoidal signals with different frequencies. The output time is controlled. This design uses sinusoidal (or sinusoid) periodic magnetic field instead of pulsed magnetic field stimulation and electrical stimulation to act on the animal brain. To observe the effect of periodically changing magnetic field on the learning and memory ability of animals, the effect of continuous periodic magnetic field on brain is different from that of pulse magnetic field and static constant magnetic field. It will be a new exploration of the interaction between magnetic field and nerve. The functional design of transcranial magnetic induction system makes the operation simple and convenient. The behavioral training and testing of animal learning and memory showed that the system was helpful to increase memory. At the same time, in order to better demonstrate the effect of transcranial magnetic induction. The results show that magnetic induction can change the distribution of EEG power spectrum. These experimental results not only verify the rationality and feasibility of the theory. It also opens up a new application field for magnetic induction and provides a new way to improve memory.
【学位授予单位】：天津大学
【学位级别】：硕士
【学位授予年份】：2009
【分类号】：R312

【引证文献】