DNA甲基化与健康长寿的研究进展

发布时间：2018-01-05 05:32

本文关键词：DNA甲基化与健康长寿的研究进展　出处：《中国老年保健医学》2015年04期 　论文类型：期刊论文

【摘要】：表观遗传修饰在基因调控的过程中起重要作用,抑制疾病发生的相关基因在健康长寿的个体中可能也受到表观遗传修饰,从而参与促进健康长寿的表型。年龄相关的DNA甲基化改变,涉及到老年个体中的代谢性疾病、心血管疾病、肿瘤等增龄性疾病的发生与发展。关于长寿和延缓衰老的作用目前基于基因变异领域得到支持性的证据有限,但近年来DNA甲基化的增龄性变化模式已经得到多个人群证实贯穿于生命全程而存在,其改变受到性别和年龄阶段影响,这将是我们认识生命发生发展的重要科学突破口。但是对于DNA甲基化的发生原因和确切机制还需要未来进一步研究,未来对于认识衰老、延缓衰老,以及个体化"精准"监测衰老进程和干预疗效,将提供更为广阔的前景。
[Abstract]:Epigenetic modification plays an important role in the process of gene regulation, and genes related to the inhibition of disease may also be modified by epigenetic modification in healthy and long-lived individuals. Thus participate in the phenotype of promoting health and longevity. Age-related DNA methylation changes are involved in metabolic disease cardiovascular disease in the elderly. The occurrence and development of age-related diseases such as tumours. The role of longevity and delayed aging is currently supported by limited evidence in the field of genetic variation. However, in recent years, the aging pattern of DNA methylation has been confirmed by many people throughout life and its changes are affected by sex and age stage. This will be an important scientific breakthrough for us to understand the occurrence and development of life, but the cause and exact mechanism of DNA methylation need further study in the future. And individualized "accurate" monitoring of aging process and intervention efficacy, will provide a broader prospect.
【作者单位】：北京老年医学研究所卫生部老年医学重点试验室;北京医院;
【基金】：北京市科技新星计划(Z121107002512058) 国家自然科学基金(30972709,81061120527,81241082,81370445) 卫生部公益性研究基金(201302008) 国家科技部十二五支撑计划项目(2012BAI10B01)
【分类号】：R363
【正文快照】： 遗传变异在解释人类长寿中的比例仅占20%~30%,但是大部分潜在的遗传学机制还并不清楚[1,2]。表观遗传(Ep-igenetics)修饰在基因调控的过程中起重要作用,抑制疾病发生的相关基因在健康长寿的个体中可能也受到表观遗传修饰,从而参与促进健康长寿的表型。DNA甲基化是表观遗传学的

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