慢性应激与血压、血糖、血脂、血清皮质醇、肾上腺素、去甲肾上腺素和5-HTTLPR的关系

发布时间：2018-01-08 08:00

  本文关键词：慢性应激与血压、血糖、血脂、血清皮质醇、肾上腺素、去甲肾上腺素和5-HTTLPR的关系　出处：《中国人民解放军军医进修学院》2010年博士论文　论文类型：学位论文

  更多相关文章： 应激 血压 血糖 血脂 氢化可的松 肾上腺素 去甲肾上腺素 5-HTTLPR多态性

【摘要】： 目的：1.探讨慢性应激与血压、血糖和血脂的关系。2.研究慢性应激与血清皮质醇、肾上腺素和去甲肾上腺素的关系。3.评价慢性应激与5-HTTLPR基因多态性的关系。 方法：选择驻守戈壁的某部军人847人作为研究对象,使用特质应对方式问卷、领悟社会支持量表和90项症状清单评测其应激状态,测量收缩压和舒张压,测定空腹血糖、口服葡萄糖耐量实验2h血糖和血清总胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇,检测血清皮质醇、肾上腺素和去甲肾上腺素浓度,使用聚合酶链式反应技术和琼脂糖凝胶电泳技术分析5-HTTLPR的基因多态性,将数据进行统计学处理。 结果：1.研究对象SCL-90高于SCL-90中国成人常模(P0.01)；NC与FPG、OGTT2hPG、TC、1gTG和LDL-C存在线性关系(P0.05),PC与FPG存在线性关系(P0.05),SCL-90与SBP、FPG,OGTT2hPG、TC、lgTG和LDL-C存在线性关系(P0.05)；NC是TC和LDL-C的影响因素(b=0.013,0.008),PC是FPG的影响因素(b=-0.006),SCL-90是SBP、OGTT2hPG、TC、1gTG和LDL-C的影响因素(b=0.014,0.002,0.002,0.001,0.001)。2.研究对象COR, E和NE与正常人测量值未见显著差异(P0.05),SCL-90与COR、E和NE存在线性关系(P0.05),NC与COR和E存在线性关系(P0.05)；NC和SCL-90是E的影响因素(b=0.385,0.054)。3.5-HTTLPR多态性的等位基因与研究对象的应激状态相关,即不同等位基因的NC和SCL-90评分差异有统计学意义(χ2=21.232、30.359,P均小于0.05),携带S等位基因的个体应激水平较高；NC和SCL-90评分组Ⅰ高于组Ⅱ(P0.05),S／S基因型个体的应激水平高于S／L和L／L基因型个体。 结论：1.长期驻守戈壁的军人应激水平高于正常人,慢性应激可能与高血压、高血糖和高血脂的发病相关。2.慢性应激可能导致血清肾上腺素浓度升高。3.S等位基因相对L等位基因对应激易感,S／S基因型个体相对S／L和L／L基因型个体,可能产生较高应激水平。
[Abstract]:Objective 1. To investigate the relationship between chronic stress and blood pressure, blood glucose and blood lipid. 2. To study the relationship between chronic stress and serum cortisol. Relationship between epinephrine and norepinephrine. To evaluate the relationship between chronic stress and 5-HTTLPR gene polymorphism. Methods: a total of 847 soldiers stationed in Gobi were selected to evaluate their stress state with trait coping style questionnaire, perceived social support scale and 90 symptom lists. Systolic blood pressure (SBP) and diastolic blood pressure (DBP), fasting blood glucose (FBG), 2 h glucose level in oral glucose tolerance test and serum total cholesterol, triglyceride, low density lipoprotein cholesterol and high density lipoprotein cholesterol were measured. Serum cortisol, epinephrine and norepinephrine concentrations were detected. The gene polymorphisms of 5-HTTLPR were analyzed by polymerase chain reaction and agarose gel electrophoresis. Statistic the data. Results 1. The SCL-90 of the subjects was higher than that of SCL-90 Chinese adult norm (P0.01A). There was a linear relationship between NC and OGTT _ 2hPGT _ 2g TG and LDL-C. There was a linear relationship between PC and FPG (P _ (0.05)). There was a linear relationship between SCL-90 and OGTT2hPGG TG and LDL-C. NC is the influencing factor of TC and LDL-C. PC is the influence factor of FPG. SCL-90 is SBP. The influencing factors of 1 g TG and LDL-C of OGTT2hPGN were 0.014 ~ 0.002 ~ 0.002 ~ 0. 001 ~ 0. 001. There was no significant difference between the measured values of Corr, E and NE and that of normal subjects (P 0.05), SCL-90 and COR. There is a linear relationship between E and NE. There is a linear relationship between NC and COR and E. The alleles of NC and SCL-90 were the influencing factors of E, the alleles of 0.385 and 0.054. 3.5-HTTLPR polymorphism were associated with the stress state of the subjects. The scores of NC and SCL-90 of different alleles were significantly different (蠂 2, 21.232, 30.359, P < 0.05). The stress level of individuals with S allele was higher than that of individuals with S allele. The stress level of group 鈪，

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