2011-2013年广州地区发热呼吸道感染患者的人流感病毒监测及其亚型的流行特征分析

发布时间：2018-01-17 03:13

本文关键词：2011-2013年广州地区发热呼吸道感染患者的人流感病毒监测及其亚型的流行特征分析　出处：《热带医学杂志》2015年12期 　论文类型：期刊论文

【摘要】：目的了解2011-2013年广州地区发热呼吸道症候群患者的人流感病毒及其亚型流行特征。方法收集广州市2011-2013年5家哨点医院共2 085例发热同时伴随有呼吸道感染症状病人的咽拭子标本及相关临床信息,对人流感病毒进行筛查,并结合临床信息,分析其流行特征。结果 2011-2013年收集到的2 085份样本中237例经普通PCR检测为人流感病毒阳性,检出率为11.4%,其中人流感病毒甲型和乙型阳性的标本分别为202例和35例(阳性率分别为9.68%和1.68%),以甲型流感为主;人流感病毒阳性率最高组别为学生(大中小学生)组,就诊率最高科室为儿科;男女比例1.34:1,性别发病率差异无统计学意义;亚型流行高峰呈不均匀分布,其中流感病毒甲型发病高峰为3-5月;流感病毒乙型分布较为分散;广州地区人流感病毒是以0~岁组、7~岁组及18~39岁年龄组易感,各年龄组发病率差异有统计学意义;广州地区甲型流感病毒也是以18~39岁组高发,各年龄组发病率差异无统计学意义;乙型感染则以7~17岁组发病率最高。结论 2011-2013年广州并未暴发大型的人流感病毒疫情,人流感病毒以甲型流感为主,乙型流感也有散发,未发现丙型流感病毒感染;流行高峰出现在3-5月,18~39岁年龄组发病率最高。
[Abstract]:Objective to investigate the epidemic characteristics of human influenza virus and its subtypes in patients with fever and respiratory syndrome (FRS) in Guangzhou from 2011 to 2013. Methods 5 sentinel hospitals in Guangzhou from 2011 to 2013 were collected. Pharynx swabs and clinical information of 085 patients with fever associated with respiratory tract infection. Screening of human influenza viruses and clinical information. Results among the 2 085 samples collected from 2011 to 2013, 237 cases were tested positive for human influenza virus by general PCR, and the positive rate was 11.4%. The positive rates of human influenza virus A and B were 9.68% and 1.68 respectively. The highest positive rate of human influenza virus was in the group of students (middle and college students), and the highest rate of consultation was in pediatrics. The ratio of male to female was 1.34: 1, and there was no significant difference in the incidence of sex. The epidemic peak of subtype was unevenly distributed, and the peak of influenza A infection was 3-5 months. The distribution of influenza B virus was scattered. Influenza virus was susceptible to influenza virus in 0 ~ year old group and 1839 year old group in Guangzhou area. The incidence of influenza virus in each age group was significantly different. The incidence of influenza A virus was also high in 1839 years old group in Guangzhou area, and there was no significant difference in the incidence of influenza A virus among different age groups. Conclusion there was no large-scale human influenza virus outbreak in Guangzhou from 2011 to 2013. Human influenza virus was mainly influenza A and influenza B was also distributed. No influenza C virus infection was found. The highest prevalence occurred in the age group of 18 ~ 39 years of age in 3-5 months.
【作者单位】：中山大学临床检验标准化研究中心;广东省人民医院(广东省医学科学院)病理医学部检验科;中山大学中山医学院微生物教研室;中山大学热带病防治研究教育部重点实验室;广东省重大传染病预防和控制中心;
【基金】：国家重大传染病防治科技重大项目(2012ZX10004-213)
【分类号】：R373.13
【正文快照】： 人流感病毒根据病毒核蛋白(NP)和基质蛋白(M蛋白)抗原性不同,可分为甲(A)、乙(B)、丙(C)三型,主要在呼吸道增殖,很少入血,但是在代谢过程中产生的毒素样物质可进入血流引起发热、头痛和全身酸痛。人流感病毒感染一般数日能自愈,但幼儿或老年体弱多病者易继发细菌感染,合并肺炎

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