近年链霉菌次生代谢产物研究进展

发布时间：2018-02-04 00:50

本文关键词： 链霉菌次生代谢产物研究进展　出处：《中国抗生素杂志》2015年10期 　论文类型：期刊论文

【摘要】：链霉菌属微生物可合成生物碱、蒽醌、内酯、黄酮及酚类等结构多样的次生代谢产物;同时,这些代谢物质还具备拮抗微生物、抗肿瘤、酶抑制等多种生物活性。但随着链霉菌代谢产物研究在20世纪70年代达到巅峰后,在随后的20年间新物质的发现比率不断下降;该领域研究的未来发展前景如何一直是关注的热点。本文依据2005—2013年期间链霉菌次生代谢研究报道数据,针对新化合物数量、结构类型、生物活性及菌株采样环境进行分类统计分析,并对典型新化合物进行介绍。分析结果表明:针对链霉菌次生代谢产物研究,自2009年以来新结构活性化合物数量逐年增多;随着新技术、新方法的普及,链霉菌这一传统先导化合物研究材料依然具备重要的研究价值。
[Abstract]:Streptomyces can synthesize alkaloids, anthraquinones, lactones, flavonoids, phenols and other secondary metabolites. At the same time, these metabolites also have many biological activities, such as antagonistic microorganism, anti-tumor, enzyme inhibition and so on. But with the research of the metabolites of Streptomyces reached its peak in 1970s. The rate of discovery of new substances continued to decline over the next 20 years; According to the data of Streptomyces secondary metabolism from 2005 to 2013, this paper aims at the quantity and structure type of new compounds. The biological activity and strain sampling environment were classified and analyzed, and the typical new compounds were introduced. The results showed that the secondary metabolites of Streptomyces were studied. Since 2009, the number of new structure-active compounds has increased year by year. With the popularization of new technologies and methods, Streptomyces, a traditional leading compound, still has important research value.
【作者单位】：云南大学云南省微生物研究所;四川医科大学基础医学院;
【基金】：国家自然科学基金云南特殊碱性环境真菌Siderophore结构多样性及其生物学功能考察(No.31260012);国家自然科学基金新磷氮霉素A防治作物灰霉病的深入筛选(No.B020901);国家自然科学基金3株云南盐矿耐(嗜)盐真菌次生代谢产物与活性研究(No.21402169) 云南省中青年学术技术带头人后备人才项目(No.2011CI001)
【分类号】：R37
【正文快照】： 2四川医科大学基础医学院,泸州646000)链霉菌,具有丝状分枝菌丝的革兰阳性细菌,来源于土壤、海洋或以内生菌的形式存在于动植物体内。链霉菌在分类学上属原核生物界放线菌目链霉菌科,与其他细菌相比,链霉菌具有较为复杂的生活周期,在形态分化的同时伴随着复杂的生理变化和多种

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