毛细血管的新生方式与组织缺氧程度的关系的研究

发布时间：2018-03-08 21:13

本文选题：血管新生方式　切入点：出芽式血管新生　出处：《苏州大学》2009年硕士论文　论文类型：学位论文

【摘要】： 毛细血管新生的主要方式为出芽和套叠,它们出现于不同的生理(机体生长过程)或病理(肿瘤和创伤修复等)条件下。近年来的文献表明目前对血管新生方式的研究主要集中在现象的观察描述和数学模拟,以及分子水平上阐述套叠和出芽过程中各种因子的作用。对于何种情况下采用出芽式血管新生,何种情况下采用套叠式还没有明确的认识。本研究以探讨组织缺氧程度对血管新生方式的影响为目标。通过大鼠解剖实验观察机体生长过程毛细血管新生的主要方式;通过模型构建从理论上分析比较机体生长过程、肿瘤生长和创伤修复过程中组织的缺氧程度;结合各种生理和病理情况下血管新生的方式进行讨论。研究的主要内容包括以下两部分。第一部分主要是通过实验观察研究机体发育过程中组织缓慢缺氧情况下(机体生长)毛细血管新生的主要方式。根据套叠和出芽发生时毛细血管的形态,判定大鼠长伸肌生长过程血管新生的主要方式;结合组织的缺氧程度,探讨血管新生和组织缺氧程度的关系。结果得知,大鼠长伸肌生长过程血管新生的主要方式为套叠,因机体生长过程是缓慢的缺氧进程,所以推定缓慢缺氧情况下,血管新生的主要方式为套叠。第二部分主要通过构建生长及血管形成模式从理论上探讨不同缺氧程度下血管新生的主要方式,分析比较机体生长过程、肿瘤生长和创伤修复过程中组织的缺氧程度,阐明启用不同种血管新生方式的形成机制。结果得知,机体生长过程组织的缺氧程度较小,为缓慢缺氧,血管新生的主要方式为套叠,所以缓慢缺氧情况下血管新生的主要方式为套叠;肿瘤生长过程组织的缺氧程度次之,为中度缺氧,前期血管新生的主要方式为出芽,后期即缓和生长期出现套叠式血管新生,所以中度缺氧情况下两种方式共存;创伤修复过程中,组织的缺氧程度为急性,此条件下血管新生的主要方式为出芽。毛细血管新生方式与组织缺氧程度的关系探知有助于进一步了解血管新生方式的机制,探讨毛细血管网络,设计有利于血管生长的生物医用材料;有助于治疗由血管新生引发的疾病。相信我们的研究对更进一步认识由血管新生引发的生理、病理情况有重要的理论及临床上的参考作用。
[Abstract]:The main ways of capillary regeneration are sprouting and overlaying. They occur in different physiological (body growth processes) or pathological (tumor and wound repair) conditions. Recent studies have shown that recent studies of angiogenesis have focused on the observation, description and mathematical simulation of phenomena. And at the molecular level, explain the role of various factors in the process of overlay and budding. When to use budding angiogenesis, The purpose of this study was to explore the effect of tissue hypoxia on angiogenesis, and to observe the main ways of capillary neovascularization in the process of organism growth through rat anatomical experiments. The degree of hypoxia in the process of body growth, tumor growth and wound repair was analyzed and compared theoretically by model building. The main contents of this study are as follows: (1) Angiogenesis under various physiological and pathological conditions. The first part is to observe and study the main ways of capillary neovascularization in the slow anoxia of tissues during the development of the body, according to the morphology of capillaries at the time of intussusception and budding. The relationship between angiogenesis and tissue anoxia was studied. The results showed that the main pattern of angiogenesis during the growth of extensor longus in rats was intussusception. Because the growth of the body is a slow anoxic process, it is assumed that the main way of angiogenesis in slow hypoxia is intussusception. The second part mainly discusses the main ways of angiogenesis under different degrees of hypoxia by constructing growth and angiogenesis models, and analyzes and compares the degree of hypoxia in the process of body growth, tumor growth and wound repair. The results showed that the degree of hypoxia in the tissue was relatively small, which was slow anoxia, and the main way of angiogenesis was overlay. So the main way of angiogenesis under slow anoxia is intussusception; the degree of anoxia in tumor growth process is secondary to moderate hypoxia, and the main way of angiogenesis in the early stage is budding, that is, in the later stage of palliative growth, the overlapping angiogenesis occurs. In the process of wound repair, the degree of tissue hypoxia is acute, and the main way of angiogenesis under this condition is sprouting. The relationship between capillary neovascularization and tissue hypoxia is helpful to further understand the mechanism of angiogenesis, explore capillary network, and design biomedical materials conducive to vascular growth. It is believed that our research has important theoretical and clinical reference value for further understanding the physiological and pathological conditions caused by angiogenesis.
【学位授予单位】：苏州大学
【学位级别】：硕士
【学位授予年份】：2009
【分类号】：R363

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