房颤动物模型及其在细胞和分子疗法研究中的应用进展

发布时间：2018-04-19 20:49

本文选题：房颤 + 动物疾病模型　；参考：《中国实验动物学报》2015年02期

【摘要】：房颤是多原因引起的心律失常,可导致运输到各器官组织的血量不足,引发血栓、心衰或其他相关的复杂病情。房颤的动物模型分类根据其疾病的症状或诱发因素可分为电生理性模型、神经激素和血管生理失常模型和结构变异模型等。不断涌现的新技术如microRNA、CRISPR-Cas9体系等为构建房颤疾病动物模型提供了新的技术手段并引导其在疗法研究上的应用新方向。目前房颤治疗方法的研究已经从传统的侵入式电生理方法和抗心律失常药物的使用转向细胞和分子疗法,并在房颤分子机理、靶向治疗和药物筛选等方面都有重要的新进展。本文综述了几类常见的房颤动物模型的构建和特性及其在细胞和分子疗法研究中的应用进展。
[Abstract]:Atrial fibrillation (AF) is an arrhythmia caused by multiple causes, which can lead to insufficient blood flow to various organs and tissues, thrombosis, heart failure, or other related complex conditions. The animal model classification of atrial fibrillation can be divided into electrical physiological model, neurohormone and vascular physiological abnormality model and structural variation model according to the symptoms or inducing factors of the disease. The emerging new technologies, such as microRNA-CRISPR-Cas9 system, provide a new technique for the construction of animal models of atrial fibrillation disease and guide its application in therapy research. At present, the research of atrial fibrillation treatment has changed from the traditional invasive electrophysiological methods and the use of antiarrhythmic drugs to cell and molecular therapy, and there are important new advances in the molecular mechanism of atrial fibrillation, targeted therapy and drug screening. In this paper, the construction and characteristics of several common animal models of atrial fibrillation and their applications in cell and molecular therapy are reviewed.
【作者单位】：广东医学院;广东省实验动物重点实验室;复旦大学附属中山医院;广东省实验动物监测所;广东医学院附属医院;
【基金】：广东省实验动物重点实验室开放课题(No.2013061402001) 国家自然科学基金青年项目(No.81200086)
【分类号】：R541.75;R-332

【共引文献】