致病性曲霉的耐药性研究进展

发布时间：2018-05-06 01:26

本文选题：曲霉 + 耐药　；参考：《微生物与感染》2015年02期

【摘要】：随着抗真菌药物在临床上的广泛使用,致病性真菌的耐药率越来越高,耐药曲霉对侵袭性曲霉病的诊治产生了重要影响。目前,致病性曲霉耐药性的确定主要依靠抗真菌药敏试验和分子诊断。在有关曲霉耐药机制的研究中,报道最多的是曲霉对唑类药物的耐药,其机制主要包括外排泵表达增加、靶酶Cyp51突变和表达水平增高、形成生物膜,以及热休克蛋白90(Hsp90)介导的信号通路参与而导致的耐药。本文就上述领域近年来的主要进展进行综述。
[Abstract]:With the wide use of antifungal drugs in clinic, the drug resistance rate of pathogenic fungi is higher and higher. The drug resistance of Aspergillus sp. Has played an important role in the diagnosis and treatment of invasive aspergillosis. At present, the determination of drug resistance of Aspergillus mutans mainly depends on antimicrobial susceptibility test and molecular diagnosis. Among the studies on drug resistance of Aspergillus sp., the resistance of Aspergillus to Azoles was reported most frequently. The mechanisms include increased expression of efflux pump, mutation and expression level of target enzyme Cyp51, and formation of biofilm. And heat shock protein 90 (Hsp90)-mediated signal pathway involved in drug resistance. This paper reviews the main progress in the above fields in recent years.
【作者单位】：北京大学第一医院皮肤性病科;北京大学真菌与真菌病研究中心皮肤病分子诊断北京市重点实验室;
【基金】：国家自然科学基金(81471925) 教育部“新世纪人才支持计划”(NCET-10-0198)
【分类号】：R379

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