生物反馈改变正常人群生理功能的非线性研究

发布时间：2018-07-08 14:13

本文选题：生物反馈 + 人体对照试验　；参考：《中国现代医学杂志》2015年35期

【摘要】：目的借助近似熵(Ap En)和交叉近似熵(Cross-Ap En),研究生物反馈过程中脑电、心电的变化,从而发现生物反馈对机体的治疗机制。方法 60例健康受试者纳入研究,其中30例为生物反馈实验组,30例为正常对照组。以肌电生物反馈作为反馈方法,同时记录脑电和心电的变化,每次生物反馈刺激间隔3 d,作为一个生物反馈阶段,总共7个阶段。采集的数据进行近似熵和交叉近似熵的非线性研究。结果心电方面,随着实验进展,心电Ap En增高。脑电方面,脑电Ap En早期无明显变化,但在最后2次生物反馈阶段可见额叶脑电Ap En升高。当综合分析心电和脑电的关联时,每个生物反馈阶段的EC值[脑电(EEG)和心电图(ECG)之间的Cross-Ap En值]均不同程度地升高,在第3和7实验阶段有2个明显的高值。结论该实验观察生物反馈过程中2种生理学指标的变化,同时通过一种新的数学方法进行研究,发现生物反馈能够同时影响心电生理和脑电生理系统,使2个系统表现出更加良好的神经网络协调性和自我组织的整合能力,揭示生物反馈潜在的治疗机制。
[Abstract]:Objective to study the changes of electroencephalogram (EEG) and electrocardiogram (ECG) in the process of biofeedback by means of approximate entropy (AP E n) and cross approximation entropy (Cross-Ap E n), and to find out the therapeutic mechanism of biofeedback. Methods 60 healthy subjects were included in the study, 30 of them were biofeedback experimental group and 30 were normal control group. EMG biofeedback was used as a feedback method. The changes of EEG and ECG were recorded at the same time. The interval of biofeedback stimulation was 3 days. As a biofeedback stage, there were 7 stages. The nonlinearity of approximate entropy and cross approximate entropy are studied. Results in ECG, with the development of experiment, AP E n was increased. In EEG, there was no obvious change of ApEn in the early stage of EEG, but in the last two biofeedback stages, there was an increase in ApEn in frontal lobe. When the correlation between ECG and EEG was analyzed synthetically, the cross-Ap en value between EEG and ECG increased in each biofeedback stage, and there were two significant high values in the 3rd and 7th experimental stages. Conclusion the changes of two physiological indexes in the process of biofeedback were observed, and a new mathematical method was used to study the effects of biofeedback on both electrocardiology and electrophysiologic system. The two systems show better neural network coordination and self-organization integration ability, and reveal the potential therapeutic mechanism of biofeedback.
【作者单位】：广州医科大学附属第二医院神经内科;
【基金】：国家自然科学基金(No:81371573) 广东省科技计划资助项目(No:2012B031800435)
【分类号】：R33-3

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