犬、猪、羊与人冠状动脉分支分布的比较研究

发布时间：2018-07-25 07:28

【摘要】： 目的:本研究作为心律失常的电生理机制研究的解剖学基础部分,就试图比较狗、猪、羊与人冠状动脉分布,为选择人类合适的动物模型提供理论依据。方法:选取家狗、家猪、绵羊各30只,分别制作冠状动脉的血管铸型标本,测量狗、猪与羊的冠状动脉分布,所得计数资料采用SSPS13.0软件x2检验进行统计学分析,检验水准α=0.05。结果:狗左心室93.3%由前降支供血,猪50%由前降支供血,羊90%由旋支供血,而人70%由前降支供血,狗、羊与人的差异有统计学意义(p0.05),猪与人比较无统计学意义。狗右心室66.7%由右冠状动脉供血,猪80%由右冠状动脉供血,羊90%由右冠状动脉供血,人80%由右冠状动脉供血,狗、猪、羊与人比较均无统计学意义。狗的室间隔80%由前降支供血,猪43.3%由右冠状动脉供血,羊93.3%由前降支供血,人80%由前降支供血,猪与人的差异有显著统计学意义(p0.01),狗、羊与人比较无统计学意义。狗窦房结(SAN)93.3%由右冠状动脉供血,猪100%由右冠状动脉供血,羊66.7%由右冠状动脉供血,人70%由右冠状动脉供血,猪与人的差异有显著统计学意义(p0.01),狗、羊与人比较无统计学意义。狗房室结90%由旋支供血,猪93.3%由右冠状动脉供血,羊100%由旋支供血,人93.3%由右冠状动脉供血,狗、羊与人的差异有显著统计学意义(p0.01),猪与人比较无统计学意义。狗心肌桥的出现率、部位与人相似。狗与羊后壁的优势分布几乎均为左优势型,猪80%为右优势型,而人70%为右优势型。狗、羊与人的差异有显著统计学意义(p0.01),猪与人比较无统计学意义。结论:狗、羊适合作为人类右心室、室间隔、侧支循环、窦房结与心肌桥研究的动物模型;而猪适合作为人类左右心室、房室结、优势分布研究的动物模型。
[Abstract]:Objective: as the anatomical basis of electrophysiological mechanism of arrhythmia, this study attempts to compare the distribution of coronary arteries between dogs, pigs, sheep and human, and to provide theoretical basis for the selection of suitable animal models. Methods: 30 domestic dogs, 30 domestic pigs and 30 sheep were selected to make coronary artery casting specimens, and the coronary artery distribution of dogs, pigs and sheep were measured. The counting data were statistically analyzed by SSPS13.0 software x2 test. Results: 93.3% of the left ventricle was supplied by anterior descending branch, 50% by anterior descending branch, 90% by circumflex branch in sheep, and 70% by anterior descending branch in human. The difference between dog, sheep and human was statistically significant (p0.05). There was no significant difference between pig and human. 66.7% of the right ventricle was supplied by the right coronary artery, 80% by the right coronary artery in pigs, 90% by the right coronary artery in sheep, and 80% by right coronary artery in human. There was no significant difference between dog, pig and sheep. The ventricular septum was supplied by anterior descending branch in 80% of dogs, by right coronary artery in 43.3% of pigs, by anterior descending branch in 93 3% of sheep and by anterior descending branch in 80% of patients. There was significant difference between pig and human (p0.01), but there was no significant difference between dog and sheep. The (SAN) of sinoatrial node in dogs was 93.3% from the right coronary artery, 100% from the right coronary artery, 66.7% from the right coronary artery in sheep and 70% from the right coronary artery in human. The difference between pig and human was statistically significant (p0.01), but there was no significant difference between dog and sheep. 90% of dog atrioventricular node was supplied by circumflex branch, 93 3% by right coronary artery, 100% by circumflex branch in sheep and 93 3% by right coronary artery in human. There was significant difference between dog and sheep (p0.01), but there was no significant difference between pig and human. The occurrence rate of myocardial bridge in dogs is similar to that in human. The dominant distribution of the posterior wall of dog and sheep was almost left dominant, 80% of pig was right dominant, and 70% of human was right dominant. There was significant difference between dog, sheep and man (p 0.01), but there was no significant difference between pig and man. Conclusion: dogs and sheep are suitable animal models for the study of human right ventricle, ventricular septum, collateral circulation, sinoatrial node and myocardial bridge, while pigs are suitable for the study of the distribution of human left and right ventricle, atrioventricular node and dominant distribution.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2008
【分类号】：R322.1

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