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数字化国人膝关节形态学测量在人工膝关节领域的应用研究

发布时间:2018-07-28 12:59
【摘要】: 目的:随着中国人口的不断老龄化以及老年人膝关节的退行性改变,使得国人人工膝关节置换手术变得越来越普遍,因此人工膝关节置换术后的成功率和人工膝关节假体的使用寿命也就成为了人们关注的重点。人工膝关节置换手术是一项精确的手术,在人工膝关节置换手术中,精确的截骨量、截骨角度以及假体的形态学匹配度是影响人工膝关节置换手术成功的关键。本研究通过对正常国人膝关节CT扫描,扫描图像的三维重建,以及重建膝关节模拟人工膝关节置换手术进行胫骨近端和股骨远端的截骨、形态学测量和统计分析,比较国人膝关节形态学大小与国内外目前使用的膝关节形态尺寸之间的差异,同时进行国人人工膝关节形态的大小设计,为指导适合国人人工膝关节的生产提供形态学依据。 方法:通过CT扫描收集120个正常国人—志愿者膝关节的CT扫描图像,应用三维重建软件进行国人膝关节扫描图像的三维重建,建立数字化国人膝关节模型,对重建膝关节三维模型模拟人工膝关节置换手术,在内侧胫骨平台下方6mm保持7度后倾角进行膝关节胫骨近端截骨,在股骨远端内侧髁最低点上方9mm保持6度外翻角进行股骨远端截骨,测量截骨断面的前后径(AP)、左右径(ML)及其它主要的相关参数,对测量结果进行统计分析,并与国内外使用的部分人工关节假体形态尺寸进行比较,观察假体形态与国人膝关节形态的差距。根据相关测量统计数据进行国人人工膝关节的形态设计,在形态学上为国人人工膝关节的设计提供理论依据。 结果:通过CT扫描收集到正常国人膝关节CT图像120套,扫描范围为膝关节的关节线以上20cm,关节线以下20cm。重建出120例正常国人的膝关节三维模型。模拟人工膝关节置换手术并进行了胫骨近端和股骨远端的截骨,在截骨断面进行了形态学测量,国人胫骨近端形态学测量结果:男性胫骨左右径(tML)为75.9±2.9mm,胫骨前后径(tAP)为52±2.2mm,两者的相关系数为0.50;女性胫骨左右径(tML)为69.9±2.7mm,前后径(tAP)为46.5±2.1mm,两者的相关系数为0.57;总体胫骨左右径(tML)为72.9±4.5mm,胫骨前后径(tAP)为49.6±3.5mm,两者的相关系数为0.82。 120例国人股骨远端截骨断面形态学测量结果:男性股骨左右径为(fML)为74.9±2.9mm,股骨前后径(fAP)为66.6±2.4mm,两者的相关系数为0.52;女性股骨左右径(fML)为67.1±3.2mm,股骨前后径(fAP)为61.6±2.9mm,两者的相关系数为0.63;总体股骨左右径为(fML)为71.5±4.9mm,股骨前后径(fAP)为64.3±3.7mm,两者的相关系数为0.80。 结论:国人膝关节胫骨近端tML和tAP具有较强的相关性,其中总体相关性要强于男性和女性个体相关性(男性为0.50,女性为0.57,总体为0.82)。其形态大小与国内使用的部分人工关节假体相比,结果发现假体种类中Scopio,PFC Sigma与国人膝关节形态匹配度较好,其他假体尺寸与国人膝关节的形态学存在着一定的差距。股骨远端fML和fAP具有较强的相关性,其中总体相关性要强于男性和女性个体相关性(男性为0.52,女性为0.63,总体为0.80)。其形态大小与国内使用的部分人工关节假体相比,结果发现在五种人工膝关节假体中只有NexGen与国人膝关节形态匹配度较好,其余人工膝关节假体与国人膝关节形态存在一定差距。 因总体相关性强于个体,因此在人工关节的设计中应将整个国人作为总体,同时结合国人膝关节形态大小的数据及形态学相关性,才能设计出更适合国人骨骼形态的人工关节假体。
[Abstract]:Objective: with the aging of the population in China and the degeneration of the knee joint in the elderly, the operation of artificial knee arthroplasty has become more and more common, so the success rate of the artificial knee replacement and the life of the artificial knee prosthesis have become the focus of attention. In an accurate operation, the key to the success of artificial knee arthroplasty is the precise osteotomy, the osteotomy angle, and the morphological matching degree of the prosthesis during the replacement of the knee joint. The three-dimensional reconstruction of the scanned images, and the reconstruction of the artificial knee replacement hand of the knee joint by the CT scan of the knee joint of the normal people are studied. The osteotomy, morphological measurement and statistical analysis of the proximal tibia and distal femur were performed to compare the differences between the morphological size of the knee joint of the Chinese people and the shape and size of the knee joints at home and abroad. At the same time, the size of the artificial knee joints of the Chinese people was designed to provide the morphological basis for guiding the production of human knee joint.
Methods: a CT scan was used to collect the CT scan images of the knee joint of 120 normal people, and the three-dimensional reconstruction software was used to reconstruct the three dimensional knee joint images of the Chinese people. The digital national knee joint model was established. The reconstruction of the 3D model of the knee joint was performed to simulate the replacement of the knee joint, and the 6mm of the knee was 7 degrees below the medial tibial plateau. The posterior tibial osteotomy of the knee joint was carried out and the distal femur osteotomy was maintained at the 6 degree angle of 9mm above the lowest point of the medial condyle of the distal femur. The anterior and posterior diameter of the osteotomy section (AP), the left and right diameter (ML) and other main related parameters were measured, and the results were analyzed and analyzed, and the shape ruler of some artificial joint prosthesis was used at home and abroad. A comparison was made to observe the gap between the shape of the prosthesis and the shape of the knee in the Chinese. According to the statistical data, the morphological design of the artificial knee joint was designed to provide a theoretical basis for the design of the artificial knee joints of the Chinese people.
Results: 120 sets of CT images of the knee joint of normal people were collected by CT scanning. The scanning range was above the 20cm of the joint line of the knee joint. The three-dimensional model of 120 normal Chinese knee joints was reconstructed below the joint line. The arthroplasty of the knee joint was simulated and the osteotomy of the proximal tibia and the distal femoral bone was carried out, and the shape of the osteotomy section was formed. The morphological measurements of the proximal tibia of the Chinese people: the diameter of the tibia (tML) was 75.9 + 2.9mm, the tibia diameter (tAP) was 52 + 2.2mm, and the correlation coefficient was 0.50; the left and right diameter of the tibia (tML) was 69.9 + 2.7mm, and the anterior and posterior diameter (tAP) was 46.5 + 2.1mm, and the correlation coefficient was 0.57; the total tibia diameter (tML) was 72.9 + 4.5mm, tibia and tibia. The anteroposterior diameter (tAP) was 49.6 + 3.5mm, and the correlation coefficient was 0.82..
The morphological measurements of 120 cases of the distal femur osteotomy section of the Chinese femur: the diameter of the femur (fML) was 74.9 + 2.9mm, the femur diameter (fAP) was 66.6 + 2.4mm, the correlation coefficient was 0.52, the femur diameter (fML) was 67.1 + 3.2mm, the femur diameter (fAP) was 61.6 + 2.9mm, and the correlation coefficient was 0.63, and the total femur diameter of the femur was (fML). 71.5 + 4.9mm, the anteroposterior diameter (fAP) of femur was 64.3 + 3.7mm, and the correlation coefficient was 0.80.
Conclusion: there is a strong correlation between tML and tAP in the proximal tibia of the Chinese knee joint, and the overall correlation is stronger than that of male and female individuals (male is 0.50, female is 0.57, and the total is 0.82). Compared with some artificial joint prostheses used in China, the shape and size of the prosthesis are found to be Scopio, PFC Sigma and national knee joint. The morphological matching degree is better. There is a certain gap between the other prosthesis size and the morphology of the Chinese knee joint. The fML and fAP of the distal femur have strong correlation, and the overall correlation is stronger than the male and female individual correlation (male is 0.52, the female is 0.63, and the total is 0.80). The results showed that only NexGen in the five kinds of artificial knee joint prosthesis had better matching degree of knee joint shape, and the rest of the artificial knee joint prosthesis had a certain gap with the state of the knee joint.
Because the overall correlation is stronger than the individual, the whole country should be taken as a whole in the design of the artificial joint, and the artificial joint prosthesis which is more suitable for the state of the human skeleton should be designed according to the data and the morphological correlation of the shape of the knee joint of the Chinese.
【学位授予单位】:吉林大学
【学位级别】:硕士
【学位授予年份】:2008
【分类号】:R322;R687.4

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