加减二藤汤对慢性盆腔炎大鼠模型的影响

发布时间：2018-08-13 10:53

【摘要】：目的:研究加减二藤汤对慢性盆腔炎(CPID)大鼠的组织形态学及血液流变学的影响。方法用苯酚胶浆注射法造成大鼠慢性盆腔炎模型,其中假手术组仅打开腹腔,造模2周后按分组分别予加减二藤汤高、中、低(20ml/kg、10ml/kg、5ml/kg)剂量、妇炎消胶囊(0.95g/kg)、0.9%Na Cl溶液,实验结束后肉眼观察子宫并进行病理组织学检查,同时取血进行血液流变学检测。结果模型组较假手术组大鼠体重下降,子宫肿胀度升高及病理组织形态学慢性炎症性改变,血液流变学各项指标显著升高(P0.01),加减二藤汤各剂量组用药后对上述指标均有不同程度的对抗作用(P0.05),且高剂量组在抑制子宫肿胀、减轻输卵管病变、改善慢性炎症病理学改变优于妇炎消胶囊组。结论加减二藤汤对苯酚胶浆致慢性盆腔炎大鼠模型较好的治疗效果。
[Abstract]:Aim: to study the effect of JiajiangErteng decoction on histomorphology and hemorheology of (CPID) rats with chronic pelvic inflammation. Methods the chronic pelvic inflammatory model of rats was established by injecting phenol glue. The sham operation group only opened the abdominal cavity. After 2 weeks, the rats were divided into two groups: high, middle and low (20 ml / kg 10 ml / kg / kg 5 ml / kg), Fuyanxiao capsule (0.95g/kg) 0. 9% NaCl solution, respectively. At the end of the experiment, the uterus was observed with the naked eye and the blood was taken for hemorheology examination. Results compared with the sham-operated group, the model group had lower body weight, higher uterine swelling and chronic inflammatory changes of histopathology. The indexes of hemorheology were significantly increased (P0.01). After the addition and subtraction of Erteng decoction, all the above indexes were antagonized to different degrees (P0.05), and the high dose group was inhibiting uterine swelling and alleviating fallopian tube disease. To improve the pathological changes of chronic inflammation was better than Fuyanxiao capsule group. Conclusion addition and subtraction Erteng decoction has a better therapeutic effect on chronic pelvic inflammation rat model induced by phenol paste.
【作者单位】：浙江中医药大学;浙江省中医院;
【分类号】：R285.5;R-332

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