功能性电刺激下下肢相关运动诱发的脑状态变化分析

发布时间：2018-08-25 19:10

【摘要】：目前,应用功能性电刺激(functional electrical stimulation,FES)进行中风后康复治疗已经十分普遍,但是对于FES治疗过程中大脑的状态变化却缺乏深入的研究.掌握这一变化规律有助于了解大脑在FES治疗过程中的康复机制.笔者尝试通过研究FES诱发的脑电信号,探究在治疗过程中大脑的脑电特征变化.结合FES设计了主动、被动模式(人工被动和刺激下被动)下的下肢运动实验,采集了6名受试者(4名中风患者和2名健康受试者)的数据,并利用时频分析和源定位等方法对数据进行分析.结果发现在多种实验模式下正常受试者与患者的脑电信号中均存在事件相关去同步(event-related desynchronization,ERD)现象,证实了中风患者受损后的大脑区域仍然能够被激活;在电刺激模式下ERD的强度随电刺激的增强而增大,表明适当的高强度电刺激可以为大脑提供更好的激活作用;通过源定位分析发现感觉运动区的激活在动作期较强,而在动作保持期内激活效应较差.研究结果将有助于加深认识FES对大脑的激励作用,同时为医师设计康复治疗方案提供可靠依据.
[Abstract]:At present, functional electrical stimulation (functional electrical stimulation,FES) has been widely used in post-stroke rehabilitation, but there is no in-depth study on the changes of brain state during the treatment of FES. It is helpful to understand the mechanism of brain rehabilitation during FES therapy. This paper attempts to explore the changes of EEG characteristics in the course of treatment by studying the EEG evoked by FES. In combination with FES, we designed the lower extremity motion experiment in active and passive mode (artificial passive and stimulated passive), and collected data of 6 subjects (4 stroke patients and 2 healthy subjects). Time-frequency analysis and source location are used to analyze the data. The results showed that there was event-related desynchronization (event-related desynchronization,ERD) in the EEG of both normal subjects and patients in various experimental modes, which confirmed that the brain region after stroke could still be activated. The intensity of ERD increased with the increase of electrical stimulation, which indicated that appropriate high intensity electrical stimulation could provide better activation for the brain, and the activation of sensorimotor region was stronger in the action period by source localization analysis. However, the activation effect was poor during the period of motion retention. The results will help to better understand the role of FES in brain stimulation and provide reliable basis for doctors to design rehabilitation therapy.
【作者单位】：天津大学精密仪器与光电子工程学院;美国哈佛医学院物理医学与康复学院;英国帝国理工学院生物工程系;美国圣地兄弟会儿童医院;
【基金】：国家自然科学基金资助项目(81222921,31271062,61172008,81171423,51007063) 国家科技支撑计划资助项目(2012BAI34B02) 教育部新世纪优秀人才支持计划资助项目(NCET-10-0618)
【分类号】：R338

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