PCOS合并不孕症患者心理健康状况、血清单胺类神经递质及性激素水平的关系
发布时间：2018-10-30 09:59
【摘要】： 目的:了解多囊卵巢综合征(PCOS)合并不孕症患者心理健康状况、血清单胺类神经递质浓度,并探讨心理健康状况与血清单胺类神经递质的关系以及单胺类神经递质与性激素的关系,为PCOS合并不孕症患者的综合治疗提供资料。 方法:以不孕症合并PCOS患者30例为实验组,不孕症未合并PCOS患者30例为对照组,使用精神症状自评量表(SCL-90)统计两组在抑郁、焦虑、强迫等精神症状方面因子分平均水平,并且采用库仑阵列电化学高效液相色谱检测血清单胺类神经递质浓度,包括去甲肾上腺素(NE)、多巴胺(DA)、5-羟色胺(5-HT)及其相应代谢物3-甲氧基-4-羟基苯乙醇(MHPG)、高香草酸(HVA)和3,4-双羟苯乙酸(DOPAC)、5-羟吲哚醋酸(5-HIAA),结合血清性激素水平,分析SCL-90因子分与血清单胺类神经递质浓度的相关性,以及单胺类神经递质与性激素的相关性。 结果:1、实验组PCOS合并不孕症患者SCL-90抑郁、焦虑因子分与对照组比较有统计学差异(P＜0.05),可认为PCOS组SCL-90抑郁、焦虑因子分高于非PCOS组。 2、实验组PCOS合并不孕症患者血清5-HT、5-HIAA、HVA浓度与对照组比较有统计学差异(P＜0.05),可认为PCOS组5-HT、5-HIAA、HVA浓度低于非PCOS组。 3、对SCL-90因子分与血清单胺类神经递质浓度进行相关分析,总样本60例不孕症恐怖因子分与MHPG呈正相关(r=.302;P=0.004),精神病性因子分与MHPG呈负相关(r=.093;P=0.070),人际关系敏感、敌对因子分与DOPAC分别呈负相关(r_(敏感)=-.246,P_(敏感)=0.012;r_(敌对)=-.218;P_(敌对)=0.031),精神病性因子分与DOPAC呈正相关(r=-.041;P=0.001)。PCOS组恐怖因子分与MHPG呈正相关(r=.334;P=0.071),敌对因子分与HVA、DOPAC分别呈负相关(r_(HVA)=-.313,P=0.092;r_(DOPAC)=-.416,P=0.022)。非PCOS组,未发现明显相关性。 4、PCOS患者血清单胺类神经递质与性激素浓度进行相关分析,MHPG与卵泡刺激素(FSH)呈负相关(r=-609;p=0.000),DA与FSH呈正相关(r=.162;p=0.094),5-HT与总睾酮(TT)呈负相关(r=-.360;p=0.051)。 结论:1、PCOS合并不孕症患者SCL-90抑郁、焦虑因子分较非PCOS组明显升高。 2、PCOS合并不孕症患者血清5-HT、5-HIAA、HVA浓度较非PCOS组明显下降。 3、PCOS合并心理健康问题应该得到临床医生的重视,可以尝试通过心理对症治疗和给予神经递质源类药物的综合治疗改善目前不孕症合并PCOS患者的治疗现状。
[Abstract]:Objective: to investigate the mental health and serum concentration of amine neurotransmitters in patients with polycystic ovary syndrome (PCOS) complicated with infertility. The relationship between mental health status and blood list amine neurotransmitters and between monoamine neurotransmitters and sex hormones was discussed in order to provide data for comprehensive treatment of PCOS patients with infertility. Methods: 30 cases of infertility complicated with PCOS and 30 cases of infertility without PCOS were used as experimental group and 30 cases as control group. Mental symptom Checklist (SCL-90) was used to calculate depression and anxiety in both groups. The average factor scores in mental symptoms such as compulsion were measured by Coulomb array electrochemical high performance liquid chromatography (ECLC) to detect the concentration of blood list amine neurotransmitters, including norepinephrine (NE), dopamine (DA), 5-hydroxytryptamine (5-HT) and its metabolites, 3-methoxy-4-hydroxyphenylethanol (MHPG), (HVA) and (DOPAC), 5-hydroxyindoleacetic acid (5-HIAA), combined with serum sex hormone levels. To analyze the correlation between SCL-90 factor score and serum concentration of amine neurotransmitters, and between monoamine neurotransmitters and sex hormones. Results: 1. The scores of SCL-90 depression and anxiety factor in PCOS patients with infertility in experimental group were significantly different from those in control group (P < 0. 05). It can be concluded that SCL-90 depression and anxiety factor score in PCOS group were higher than those in non PCOS group. 2. The serum 5-HT 5-HIAAA-HVA concentration of PCOS patients with infertility in the experimental group was significantly different from that of the control group (P < 0. 05). It can be concluded that the concentration of 5 HT 5 HIAA HVA in the PCOS group was lower than that in the non PCOS group. 3. The correlation between SCL-90 factor score and serum concentration of amine neurotransmitters was analyzed. There was a positive correlation between MHPG and phobic factor score in 60 cases of infertility (r.302), and a negative correlation between psychotic factor score and MHPG (r = 093). The scores of hostility factors were negatively correlated with DOPAC (r _ (sensitivity) =-.246) P _ (sensitivity) = 0.012 r _ (hostile) =-.218; P _ (hostile) = 0.031), psychotic factor scores were positively correlated with DOPAC (r-041) and MHPG (r-041); The scores of hostile factors were negatively correlated with HVA,DOPAC (r _ (HVA) =-.313P _ (0.092) P _ (DOPAC) =-.416p _ (0. 022). No significant correlation was found in non-PCOS group. 4 correlation analysis between serum monoamine neurotransmitters and sex hormone concentration in patients with PCOS showed that there was a negative correlation between serum monoamine neurotransmitters and follicle stimulating hormone (FSH) (r = 609), DA and FSH) (r = 162). There was a negative correlation between 5-HT and total testosterone (TT) (r = 0. 094), and a negative correlation between 5-HT and total testosterone (TT) (r ~ -. 360 ~ 0. 051). Conclusion: 1 the scores of SCL-90 depression and anxiety factor in PCOS patients with infertility were significantly higher than those in the non PCOS group. (2) the serum concentration of 5 HT 5 HIAA HVA in PCOS with infertility was significantly lower than that in non PCOS group. 3PCOS with mental health problems should be paid attention to by clinicians, we can try to improve the current treatment status of infertility patients with PCOS through psychotherapy and comprehensive treatment of neurotransmitter source drugs.
【学位授予单位】：中南大学
【学位级别】：硕士
【学位授予年份】：2008
【分类号】：R395;R711.75;R711.6
本文编号：2299679
[Abstract]:Objective: to investigate the mental health and serum concentration of amine neurotransmitters in patients with polycystic ovary syndrome (PCOS) complicated with infertility. The relationship between mental health status and blood list amine neurotransmitters and between monoamine neurotransmitters and sex hormones was discussed in order to provide data for comprehensive treatment of PCOS patients with infertility. Methods: 30 cases of infertility complicated with PCOS and 30 cases of infertility without PCOS were used as experimental group and 30 cases as control group. Mental symptom Checklist (SCL-90) was used to calculate depression and anxiety in both groups. The average factor scores in mental symptoms such as compulsion were measured by Coulomb array electrochemical high performance liquid chromatography (ECLC) to detect the concentration of blood list amine neurotransmitters, including norepinephrine (NE), dopamine (DA), 5-hydroxytryptamine (5-HT) and its metabolites, 3-methoxy-4-hydroxyphenylethanol (MHPG), (HVA) and (DOPAC), 5-hydroxyindoleacetic acid (5-HIAA), combined with serum sex hormone levels. To analyze the correlation between SCL-90 factor score and serum concentration of amine neurotransmitters, and between monoamine neurotransmitters and sex hormones. Results: 1. The scores of SCL-90 depression and anxiety factor in PCOS patients with infertility in experimental group were significantly different from those in control group (P < 0. 05). It can be concluded that SCL-90 depression and anxiety factor score in PCOS group were higher than those in non PCOS group. 2. The serum 5-HT 5-HIAAA-HVA concentration of PCOS patients with infertility in the experimental group was significantly different from that of the control group (P < 0. 05). It can be concluded that the concentration of 5 HT 5 HIAA HVA in the PCOS group was lower than that in the non PCOS group. 3. The correlation between SCL-90 factor score and serum concentration of amine neurotransmitters was analyzed. There was a positive correlation between MHPG and phobic factor score in 60 cases of infertility (r.302), and a negative correlation between psychotic factor score and MHPG (r = 093). The scores of hostility factors were negatively correlated with DOPAC (r _ (sensitivity) =-.246) P _ (sensitivity) = 0.012 r _ (hostile) =-.218; P _ (hostile) = 0.031), psychotic factor scores were positively correlated with DOPAC (r-041) and MHPG (r-041); The scores of hostile factors were negatively correlated with HVA,DOPAC (r _ (HVA) =-.313P _ (0.092) P _ (DOPAC) =-.416p _ (0. 022). No significant correlation was found in non-PCOS group. 4 correlation analysis between serum monoamine neurotransmitters and sex hormone concentration in patients with PCOS showed that there was a negative correlation between serum monoamine neurotransmitters and follicle stimulating hormone (FSH) (r = 609), DA and FSH) (r = 162). There was a negative correlation between 5-HT and total testosterone (TT) (r = 0. 094), and a negative correlation between 5-HT and total testosterone (TT) (r ~ -. 360 ~ 0. 051). Conclusion: 1 the scores of SCL-90 depression and anxiety factor in PCOS patients with infertility were significantly higher than those in the non PCOS group. (2) the serum concentration of 5 HT 5 HIAA HVA in PCOS with infertility was significantly lower than that in non PCOS group. 3PCOS with mental health problems should be paid attention to by clinicians, we can try to improve the current treatment status of infertility patients with PCOS through psychotherapy and comprehensive treatment of neurotransmitter source drugs.
【学位授予单位】：中南大学
【学位级别】：硕士
【学位授予年份】：2008
【分类号】：R395;R711.75;R711.6
【参考文献】
相关期刊论文 前9条
1 袁勇贵,吴爱琴,张心保;焦虑和抑郁合病的生物学研究进展[J];国外医学.精神病学分册;2000年03期
2 张向晖;刘军;苏林雁;;库仑阵列电化学高效液相色谱法测定大鼠脑组织中单胺类神经递质及代谢产物[J];医学临床研究;2007年01期
3 肖红,姚辉,侯刚,李其军,郭苏皖,吴如金;抑郁症与血浆中单胺类神经递质代谢产物[J];神经疾病与精神卫生;2002年04期
4 王佳宁;阮祥燕;;多囊卵巢综合征患者健康相关生活质量的研究[J];实用妇产科杂志;2007年10期
5 顾平;;大鼠单胺类神经递质的分布[J];上海预防医学杂志;2007年07期
6 唐怡,张春,张庆文;慢性心理刺激对生殖功能的影响[J];现代中西医结合杂志;2003年02期
7 王玉蓉,曹云霞,丛林,魏兆莲,周平;多囊卵巢综合征患者的调查及心理分析[J];安徽医科大学学报;2005年03期
8 李国屏;李小红;陈湘梅;张丽燕;;多囊卵巢综合征与精神因素、家族史、饮食、运动的相关关系分析[J];中国妇幼保健;2006年06期
9 王建红,欧阳栋,柯江维,伍庆华,王晓敏,王敏璋;心理应激雌性大鼠海马NA、5-HT与下丘脑GnRH含量的变化[J];中国老年学杂志;2005年06期
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