成年双生子血糖、血压与血脂相关指标的遗传度研究

发布时间：2018-12-12 22:45

【摘要】： 目的：描述青岛市成人双生子血糖(空腹和OGTT后2小时血糖)、血压(收缩压、舒张压)、血脂(总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、甘油三酯)相关指标的水平,并探讨遗传和环境因素对这些指标的影响程度。方法：从青岛市双生子登记系统中选择18岁以上健康成人双生子,用自动生化分析仪检测其空腹血清血糖、2小时后血糖、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、甘油三酯的浓度,血压通过袖带加压汞柱式血压计测量。采用美国ABI公司的AmpFLSTRIdentifiler试剂盒分析双生子卵性,Mx软件拟合单变量遗传模型ACE,调整性别和年龄,分析这些指标的遗传度。结果：316对双生子符合本研究要求,其中同卵双生子组178对,异卵双生子组138对。所有双生子的平均年龄为(41.5±10.4)岁,收缩压、舒张压均值为(121±20.3)、(80±14.0) mmHg,空腹血糖、2h血糖、血清总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、甘油三酯均值为(5.40±1.30)、(6.6±2.50)、(4.52±1.06)、(1.43±0.37)、(2.57±0.76)、(1.13±0.75)mmol/L。调整性别和年龄后,Mx拟合空腹血糖的最佳模型为ACE模型,甘油三酯为CE模型,其他相关指标的最适模型均为AE模型,空腹血糖、2h血糖、收缩压、舒张压、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、甘油三酯的遗传度分别为39%、56%、62%、57%、58%、62%、63%、0。结论：遗传因素对青岛地区双生子人群的空腹血糖、2h血糖、收缩压、舒张压、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇等指标有影响,而对血清甘油三酯水平无影响。
[Abstract]:Objective: to describe the blood glucose (fasting and 2 hours after OGTT), blood pressure (systolic blood pressure, diastolic blood pressure), blood lipid (total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol) in adult twins in Qingdao. The level of triglyceride) related indexes and the influence of genetic and environmental factors on these indexes were investigated. Methods: the twins of healthy adults over 18 years old were selected from the twin registration system in Qingdao. The fasting serum glucose, total cholesterol, high density lipoprotein cholesterol were measured by automatic biochemical analyzer. Low density lipoprotein cholesterol, triglyceride concentrations, and blood pressure were measured by a cuff pressurized mercury sphygmomanometer. ABI's AmpFLSTRIdentifiler kit was used to analyze the ovidity of twins, and Mx software fitted the univariate genetic model ACE, to adjust sex and age to analyze the heritability of these indexes. Results: 316 pairs of twins met the requirements of this study, including 178 pairs of identical twins and 138 pairs of heterozygotic twins. The mean age of all twins was (41.5 卤10.4) years old. The mean systolic blood pressure and diastolic blood pressure were (121 卤20.3), (80 卤14.0) mmHg, fasting blood glucose, 2h blood glucose, serum total cholesterol, high density lipoprotein cholesterol. The mean value of low density lipoprotein cholesterol (LDL-C) was (5.40 卤1.30), (6.6 卤2.50), (4.52 卤1.06), (1.43 卤0.37), (2.57 卤0.76), (1.13 卤0.75 mmol/L.). After adjusting for gender and age, the best model for Mx to fit fasting blood glucose was ACE model, triglyceride model was CE model, the best model for other related indexes was AE model, fasting blood glucose, 2 h blood glucose, systolic blood pressure, diastolic blood pressure, total cholesterol, blood glucose, systolic blood pressure, diastolic blood pressure, total cholesterol. The heritability of high density lipoprotein cholesterol, low density lipoprotein cholesterol, and triglyceride were 39, 56 and 62, 57 and 58, respectively. Conclusion: genetic factors have influence on fasting blood glucose, 2 h blood glucose, systolic blood pressure, diastolic blood pressure, total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol and so on. There was no effect on serum triglyceride level.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R394

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