替格瑞洛改善氯吡格雷抵抗急性心肌梗死患者治疗的疗效分析

发布时间：2018-02-24 13:21

  本文关键词： 急性心肌梗死 替格瑞洛 氯吡格雷　出处：《中国现代医学杂志》2017年14期 　论文类型：期刊论文

【摘要】：目的 探讨替格瑞洛在氯吡格雷抵抗急性心肌梗死患者治疗中的临床应用效果。方法 选取2012年1月-2014年12月该院收治的氯吡格雷抵抗急性心肌梗死患者100例,将其随机分为治疗组和对照组,每组50例。治疗组患者口服阿司匹林和替格瑞洛,对照组患者术后口服阿司匹林和氯吡格雷,并分别对两组患者的临床治疗情况进行比较和分析。结果 两组患者血小板计数和血小板聚集率比较,差异有统计学意义(P0.05),治疗组患者血小板计数和血小板聚集率低于对照组;两组患者二磷酸腺苷(ADP)最大聚集时间和ADP最大聚集率比较,差异有统计学意义(P0.05),治疗组患者ADP最大聚集时间和ADP最大聚集率高于对照组;两组患者治疗后超敏C-反应蛋白和P选择素水平比较,差异有统计学意义(P0.05),治疗组患者治疗后超敏C-反应蛋白和P选择素水平低于对照组;两组患者并发症发生率比较,差异有统计学意义(P0.05),治疗组患者并发症发生率低于对照组。结论 替格瑞洛改善氯吡格雷抵抗急性心肌梗死患者临床治疗的有效性和安全性具有十分重要的意义,值得进一步临床推广应用。
[Abstract]:Objective to investigate the clinical application of tigrilol in clopidogrel resistance to acute myocardial infarction. Methods 100 patients with clopidogrel resistance to acute myocardial infarction from January 2012 to December 2014 were selected. They were randomly divided into treatment group (n = 50) and control group (n = 50). Patients in treatment group were treated with aspirin and tigrilol, and patients in control group were treated with aspirin and clopidogrel after operation. Results there were significant differences in platelet count and platelet aggregation rate between the two groups (P 0.05). The platelet count and platelet aggregation rate in the treatment group were lower than those in the control group. The maximum aggregation time of adenosine diphosphate and the maximum aggregation rate of ADP were significantly different between the two groups (P 0.05). The maximum aggregation time of ADP and the maximum aggregation rate of ADP in the treatment group were higher than those in the control group. The levels of hypersensitive C-reactive protein and P-selectin were significantly lower in the treatment group than in the control group, and the incidence of complications was higher in the treatment group than in the control group. The incidence of complications in the treatment group was lower than that in the control group. Conclusion tigrilol is of great significance in improving the efficacy and safety of clopidogrel in the treatment of patients with acute myocardial infarction. It is worthy of further clinical application.
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