比索洛尔对心力衰竭大鼠氧化应激及细胞凋亡的影响

发布时间：2018-02-26 04:38

本文关键词： 比索洛尔氧化应激心力衰竭　出处：《中国老年学杂志》2017年20期 　论文类型：期刊论文

【摘要】：目的探讨比索洛尔对心力衰竭大鼠氧化应激及细胞凋亡的影响。方法选取180~200 g SD大鼠36只,普通基础饲料喂养1 w后随机分为假手术组(12只)、心力衰竭模型组(12只)、比索洛尔治疗组(12只),术后第4周开始给予比索洛尔治疗组每日1次灌胃给药(2.0 mg·kg-1·d-1),共灌胃4 w。4 w后,超声心动测定左室舒张末径(LVDS)、室收缩末径(LVDd),左室射血分数(LVEF)及短轴缩短率(FS),测定大鼠血流动力学指标:心率(HR),左心室收缩压(LVSP),左室舒张末期压(LVEDP),左心室压变化速率最大值等。测定心肌超氧化物歧化酶(SOD)和心肌丙二醛(MAD)含量。结果与假手术组比较,模型组大鼠心功能明显降低(P0.05),LVDS、LVDd明显扩大而LVEF、FS降低;SOD水平降低,MAD水平升高(均P0.05)。与模型组相比,比索洛尔治疗组心功能明显改善,LVDS、LVDd明显缩小,LVEF、FS升高,SOD水平升高,MAD水平降低(均P0.05)。结论比索洛尔可降低氧化应激水平,改善心力衰竭大鼠心功能。
[Abstract]:Objective to investigate the effects of Bisoprolol on oxidative stress and apoptosis in rats with heart failure. After 1 week of general basic feed feeding, they were randomly divided into two groups: sham-operated group (n = 12), heart failure model group (n = 12) and Bisoprolol group (n = 12). After 4 weeks of operation, patients in the treatment group were given intragastric administration of 2. 0 mg 路kg-1 路d ~ (-1) and 4 w.4 weeks later. Left ventricular end diastolic diameter (LVDS), ventricular end-systolic diameter (LVDdN), left ventricular ejection fraction (LVEF) and short axis shortening rate (FSN) were measured by echocardiography. The hemodynamic parameters of rats were heart rate (HRT), left ventricular systolic pressure (LVSPN), left ventricular end-diastolic pressure (LVEDPV), left ventricular pressure (LVV), and left ventricular pressure (LVV). The content of myocardial superoxide dismutase (SOD) and myocardial malondialdehyde (MDA) were measured. In the model group, the cardiac function of rats decreased significantly (P0.05) LVDS / LVDd increased, while LVEFFFS decreased the level of SOD and decreased the level of MAD (P0.05). Compared with the model group, LVEFFFS decreased the level of SOD and increased the level of MAD. In Bisoprolol group, the cardiac function was significantly improved. LVDd in LVDSs was significantly reduced. The increase of LVEFFS increased the level of SOD and the level of mad. Conclusion Bisoprolol can decrease the level of oxidative stress and improve the cardiac function of rats with heart failure.
【作者单位】：佳木斯大学附属第一医院心内三科;
【基金】：2016年黑龙江省卫生计生委科研课题(No.2016-298)
【分类号】：R541.6

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