老年冠心病PTCA术后支架再狭窄患者血浆IP-10水平表达及相关危险因素

发布时间：2018-03-15 11:37

本文选题：冠心病　切入点：经皮冠状动脉腔内血管成形术　出处：《中国老年学杂志》2017年10期 　论文类型：期刊论文

【摘要】：目的探讨老年冠心病经皮冠状动脉腔内血管成形术(PTCA)术后支架内再狭窄(ISR)患者血浆干扰素诱导蛋白(IP)-10水平表达及其相关危险因素。方法 90例老年冠心病患者均接受PTCA手术治疗,并植入冠状动脉支架,术后6个月行冠状动脉造影(CAG)复查。根据复查结果,分为ISR组28例,支架内无再狭窄组32例,另30例CAG结果显示冠状动脉狭窄程度50%为对照组。详细记录3组临床资料,并对血浆IP-10浓度进行测定,分析ISR发生相关危险因素。结果 ISR组血浆IP-10浓度高于支架内无再狭窄组及对照组(P0.05);支架内无再狭窄组高于对照组(P0.05);Logistic回归分析结果显示,吸烟史、支架长度、糖尿病史、血清尿酸、血清总胆红素及血浆IP-10表达水平与ISR发生存在相关性(P0.05),是ISR发生高危因素。结论老年冠心病患者经PTCA治疗后,IP-10水平表达较高可作为临床诊断冠心病术后ISR的生化指标之一;吸烟史、支架长度、糖尿病史、血清尿酸、血清总胆红素是术后ISR发生高危因素,对具备这些高危因素的患者应强化药物治疗,及早控制。
[Abstract]:Objective to investigate the expression and risk factors of plasma interferon inducible protein (IFN) -10 in elderly patients with coronary artery disease (CHD) after percutaneous transluminal coronary angioplasty (PTCA) and restenosis in stents. Methods 90 elderly patients with coronary heart disease were enrolled in this study. Undergoing PTCA surgery, Coronary stents were implanted and coronary angiography was performed 6 months after operation. According to the results, 28 patients were divided into ISR group and 32 patients without restenosis in the stents. The results of CAG in 30 cases showed that the coronary artery stenosis degree was 50% as the control group. The clinical data of the three groups were recorded in detail, and the plasma IP-10 concentration was measured. Results the plasma IP-10 concentration in ISR group was higher than that in non-restenosis group and control group (P 0.05), and the logistic regression analysis showed that smoking history, stent length and diabetes history were higher in ISR group than those in control group. Serum uric acid, Serum total bilirubin and plasma IP-10 expression were correlated with the occurrence of ISR, which was a high risk factor for the occurrence of ISR. Conclusion the high expression of IP-10 in elderly patients with coronary heart disease after PTCA treatment can be used as one of the biochemical indexes for clinical diagnosis of ISR after coronary heart disease surgery. Smoking history, stent length, diabetes history, serum uric acid and serum total bilirubin were high risk factors for postoperative ISR.
【作者单位】：潍坊市人民医院心内二科;
【基金】：潍坊市科技局资助项目(No.201302002)
【分类号】：R541.4

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