抗氧化治疗对防治急性心肌梗死患者远期心室重构的临床研究

发布时间：2018-03-17 03:31

本文选题：心肌梗死　切入点：心室重构　出处：《中国医院药学杂志》2017年12期 　论文类型：期刊论文

【摘要】：目的:研究抗氧化剂普罗布考对防治急性心肌梗死血运重建患者远期心室重构的疗效。方法:符合纳入标准的急性ST段抬高型心肌梗死(STEMI)血运重建患者90例,按随机数字表法分为组(1)和组(2)。组(1):常规冠心病二级预防治疗;组(2):冠心病二级预防加"普罗布考"抗氧化治疗。观察指标:(1)各组患者住院期间及1年后心脏彩超结果;(2)各组患者住院期间及3个月后超氧化物歧化酶(SOD)检测结果。结果:(1)治疗前,组(1)和组(2)的基线资料、SOD水平及心脏彩超检查结果对比无差别(P0.05)。(2)1年以后复查心脏彩超结果提示:组(1)相比于组(2)发生心脏扩大患者的比率更高(P0.05);(3)3个月后复查SOD水平,组(1)与前期对比无差异(P0.05)。组(2)与前期对比SOD水平升高(P0.05)。利用二元Logistic回归模型建立数值间线性关系,得出SOD表达水平与左室舒张末内径呈负相关(B=-0.042,P0.05)。结论:氧化应激是导致心梗后进一步心室重构主要因素之一,抗氧化剂普罗布考对防治心肌梗死后心室重构的临床疗效显著,值得推广。
[Abstract]:Objective: to study the effect of antioxidant Probucol on long-term ventricular remodeling in patients with acute myocardial infarction after revascularization. According to the method of random number table, the patients were divided into two groups: group 1) and group 2: group 1: routine secondary preventive therapy for coronary heart disease; Group 2: coronary heart disease secondary prevention plus "Probucol" antioxidation therapy. Observation index: 1) the results of echocardiography during hospitalization and 1 year later) the results of echocardiography in each group (2) the superoxide dismutase (SOD) was detected during hospitalization and 3 months later. Before treatment, The baseline data of group 1) and group 2 (2) were compared with the results of cardiac color Doppler ultrasonography (P0.05) and the results of echocardiography 21 years later showed that: the ratio of patients with cardiac enlargement in group 1 was higher than that in group 2 (P 0.05)) and the level of SOD was reexamined after 3 months. Group 1) there was no difference between the two groups (P 0.05) and group 2 (P 0.05). The linear relationship between the two groups was established by using the binary Logistic regression model. Conclusion: oxidative stress is one of the main factors leading to further ventricular remodeling after myocardial infarction, and the effect of antioxidant Probucol on the prevention and treatment of ventricular remodeling after myocardial infarction is significant, conclusion: there is a negative correlation between the expression of SOD and left ventricular end-diastolic diameter (LVED). Conclusion: oxidative stress is one of the main factors leading to further ventricular remodeling after myocardial infarction. It is worth popularizing.
【作者单位】：广西壮族自治区南溪山医院心内科;
【分类号】：R542.22

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