两证型老年波动性高血压干预服务包效果评价

发布时间：2018-03-17 04:04

本文选题：高血压　切入点：血压变异性　出处：《中国老年学杂志》2017年02期 　论文类型：期刊论文

【摘要】：目的探讨两证型(血瘀证痰湿证)老年波动性高血压干预服务包的有效性及安全性。方法采用自身前后对照试验设计,对61例两证型(血瘀证痰湿证)老年波动性高血压患者实施干预服务包干预。观察干预前、后的血压变异性、患者自我监测血压、中医证候量化积分与杜氏高血压量表积分等指标及干预期间的不良反应,并进行血、尿常规及肝肾功能检查。结果干预8 w后,61例患者意向性治疗(ITT)分析显示血瘀证及痰湿证患者收缩压晨峰值(SBPMS)较干预前显著下降(P0.05),中医证候量化积分及杜氏高血压量表积分较干预前未见明显变化(P0.05);46例患者方案数据(PP)分析显示血瘀证组患者收缩压晨峰值(SBPMS)、夜间舒张压标准差(n DBP-SD)及夜间血压变异系数(n SBP-CV、n DBP-CV)较干预前明显降低(P0.05);痰湿证组患者白昼舒张压平均值(d DBP)、SBPMS、全天舒张压标准差(24h DBP-SD)及白昼舒张压标准差(d DBP-SD)较干预前明显下降(P0.05);两组患者未见明显不良反应,安全性指标无异常。结论老年波动性高血压干预服务包可以安全有效地改善两证型(血瘀证痰湿证)患者血压变异性。
[Abstract]:Objective to explore the efficacy and safety of two syndrome types (blood stasis syndrome phlegm dampness syndrome) in elderly patients with volatile hypertension intervention service package. Sixty-one elderly patients with fluctuating hypertension of two syndrome types (blood stasis syndrome phlegm dampness syndrome) were treated with intervention service package. The blood pressure variability before and after intervention was observed and the blood pressure was monitored by the patients themselves. The quantitative integral of TCM syndromes and the score of du's Hypertension scale, and the adverse reactions during the intervention period, and blood, Results the analysis of ITT in 61 patients with blood stasis syndrome and phlegm dampness syndrome showed that SBPMSwas significantly lower than that before intervention (P 0.05), the quantitative score of TCM syndromes and du's hyperglycemia were significantly lower than those before intervention. There was no significant change in the score of pressure scale compared with that before intervention. The data of 46 patients with blood stasis syndrome showed that the peak systolic blood pressure (SBPMSM), the standard deviation of night diastolic pressure (DBP-SDN) and the coefficient of variation of blood pressure at night (n SBP-CVN n DBP-CVV) were significantly lower than those before intervention. In the phlegm dampness syndrome group, the mean diurnal diastolic blood pressure (DBP) and the daytime diastolic blood pressure standard deviation (DBP-SDD) were significantly lower than those before intervention, and no significant adverse reactions were observed in the two groups. Conclusion the blood pressure variability of patients with two syndrome types (blood stasis phlegm dampness syndrome) can be improved safely and effectively by the intervention package.
【作者单位】：杭州师范大学医学院;中国中医科学院中医基础理论研究所;福建中医药大学第二临床医学院;湖北中医药大学;湖南中医药大学;
【基金】：科技部国家“十二五”支撑计划项目(No.2012BAI25B00) 国家中医药管理局中医药行业科研专项(No.201307003)
【分类号】：R544.1

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