稳心颗粒联合丁螺环酮治疗伴有ST-T改变的心脏神经症患者的疗效观察

发布时间：2018-03-27 18:12

本文选题：稳心颗粒　切入点：丁螺环酮　出处：《安徽医科大学学报》2017年03期

【摘要】：目的观察稳心颗粒联合丁螺环酮治疗伴有ST-T改变的心脏神经症的疗效。方法收集明确诊断为心脏神经症的患者90例,采用随机分组法分为安慰剂组、稳心颗粒组、联合组(稳心颗粒联合丁螺环酮),每组均30例。观察服药4周末和8周末,3组患者的汉密尔顿焦虑量表(HAMA-14)和汉密尔顿抑郁量表(HAMD-24)的得分,以及稳心颗粒联合丁螺环酮治疗12个月后的患者SF-36量表得分和ST-T改善情况。结果经治疗4周后联合组、稳心颗粒组和安慰剂组的HAMA-14和HAMD-24得分明显低于治疗前(P0.05);但第8周末比较显示,联合组HAMA-14和HAMD-24得分显著低于稳心颗粒组与安慰剂组,组间差异有统计学意义(P0.05)。3组患者随访12个月后的SF-36得分显示联合组患者的得分明显高于治疗前及其他两组(P0.05)。联合组患者随访结果显示第8周末和第12月末的ST-T改善有效率均显著高于治疗前及其他两组(P0.05)。结论稳心颗粒联合丁螺环酮治疗心脏神经症显著改善患者的焦虑及抑郁情绪,长期治疗能明显提高患者的生活质量并改善ST-T改变的躯体症状。
[Abstract]:Objective to observe the efficacy of Wenxin granule combined with buspirone in the treatment of cardiac neurosis with ST-T changes. Methods 90 patients with cardiac neurosis were selected and randomly divided into placebo group and Wenxin granule group. The scores of Hamilton anxiety scale (Hama 14) and Hamilton Depression scale (Hamd 24) were observed in three groups (Wanxin granule combined with buspirone, 30 cases in each group) at the end of 4 and 8 weeks. The scores of SF-36 scale and the improvement of ST-T after 12 months of treatment with Wenxin granule combined with buspirone. The scores of HAMA-14 and HAMD-24 in Wenxin granule group and placebo group were significantly lower than those before treatment (P 0.05), but at the end of the 8th week, the scores of HAMA-14 and HAMD-24 in combination group were significantly lower than those in Wenxin granule group and placebo group. The SF-36 score of the combined group was significantly higher than that of the patients before treatment and the other two groups after 12 months follow-up. The results of follow-up in the combined group showed that the ST-T changes occurred at the end of the 8th week and the end of the 12th month. Conclusion Wenxin granule combined with buspirone can significantly improve the anxiety and depression of patients with cardiac neurosis. Long-term treatment can significantly improve the quality of life of patients and improve the somatic symptoms of ST-T changes.
【作者单位】：安徽医科大学第一附属医院老年心内科;安徽医科大学附属巢湖医院精神科;安徽医科大学第一附属医院心理科;
【基金】：安徽高校自然科学研究重点项目(编号:KJ2016A322)
【分类号】：R541.9

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