血清可溶性肿瘤坏死因子样弱凋亡诱导因子水平与扩张型心肌病患者左心室重构的关系

发布时间：2018-03-31 06:32

本文选题：扩张型心肌病　切入点：可溶性肿瘤坏死因子样弱凋亡诱导因子　出处：《山东医药》2017年17期

【摘要】：目的探讨扩张型心肌病(DCM)患者血清可溶性肿瘤坏死因子样弱凋亡诱导因子(sTWEAK)水平变化及其与血清N-末端脑钠肽前体(NT-proBNP)和左室质量指数(LVMI)的相关性。方法选取DCM患者100例(DCM组)和非心衰患者60例(对照组),以酶联免疫吸附法检测两组血清sTWEAK和血清NT-proBNP水平,应用超声心动图测定LVMI。结果 DCM组血清sTWEAK水平低于对照组,其血清NT-proBNP水平及LVMI均高于对照组(P均0.05)。DCM组血清sTWEAK水平与其心功能NYHA分级无关,但与NT-proBNP、LVMI显著负相关(r分别为-0.524、-0.337,P均0.05),在调整性别、年龄、体质量指数、总胆固醇、低密度脂蛋白、心率、心功能NYHA分级等影响因素后,上述相关性仍然存在;多元逐步回归分析显示,DCM患者血清sTWEAK水平受LVMI的影响。结论 DCM患者血清sTWEAK水平降低,并能反映DCM患者左室重构的严重程度。
[Abstract]:Objective to investigate the changes of serum soluble tumor necrosis factor-like weak apoptosis-inducible factor (TWEAK) in patients with dilated cardiomyopathy (DCM) and its correlation with NT-proBNPs and LVMIs.Methods Serum sTWEAK and serum NT-proBNP levels were measured by enzyme-linked immunosorbent assay (Elisa) in 100 patients with DCM and 60 patients with non-CHF (control group).Results the level of serum sTWEAK in DCM group was lower than that in control group. The level of serum NT-proBNP and LVMI in DCM group was higher than that in control group. The level of serum sTWEAK in 0.05).DCM group was not correlated with NYHA grade of cardiac function, but it was negatively correlated with NT-proBNPN LVMI significantly (r = -0.524) -0.337 (P < 0.05), and adjusted for sex and age.After influencing factors such as body mass index, total cholesterol, low density lipoprotein, heart rate and NYHA grade of cardiac function, the above correlation still existed. Multivariate stepwise regression analysis showed that the level of serum sTWEAK was affected by LVMI in patients with DCM.Conclusion the level of serum sTWEAK in DCM patients is lower and can reflect the severity of left ventricular remodeling in DCM patients.
【作者单位】：郑州大学第一附属医院;
【基金】：国家自然科学基金资助项目(81070445) 河南省医学科技攻关计划项目(201403030,201403029)
【分类号】：R542.2

【相似文献】