慢性稳定型心绞痛患者PCI术后循环内皮祖细胞计数变化及其影响因素

发布时间：2018-04-04 03:38

  本文选题：循环内皮祖细胞　切入点：经皮冠状动脉介入治疗　出处：《中国动脉硬化杂志》2017年02期

【摘要】：目的研究慢性稳定型心绞痛患者经皮冠状动脉介入治疗(PCI)前后循环内皮祖细胞(EPC)的数量变化,并探讨PCI术后CD34~+/KDR~+最大动员幅度与患者内皮损伤定量参数等临床资料的相关性。方法选取93例诊断为慢性稳定型心绞痛的患者,将其中成功行PCI术治疗的72例患者作为PCI组,21例仅行冠状动脉造影术(CAG)保守治疗的患者作为对照组。采集患者股动脉鞘管或肘正中静脉血样,通过流式细胞仪对PCI组和对照组患者CAG术后即刻(基线水平)及PCI术后或CAG后1 h、3 h、5 h、7 h、24 h的EPC数量进行测定。结果不同类型的EPC在不同时间点及在PCI组和对照组两组间的总体均数存在统计学差异(P0.05)。PCI组中,与基线水平相比,CD34~+/KDR~+在24 h,CD133-/CD34~+/KDR~+在3 h、5 h、24 h,CD133~+/CD34~+/KDR~+在5 h、7 h,CD133~+/KDR~+在3 h、5 h,CD133~+/CD34~+在24 h差异有统计学意义(P0.05)。对照组中,各类型EPC在不同时间点计数与基线水平相比,无统计学差异(P0.05)。CD34~+/KDR~+最大动员幅度与C反应蛋白呈现负相关,与体质指数、服用血管紧张素转化酶抑制剂或血管紧张素Ⅱ受体拮抗剂类药物的情况、血管内皮损伤定量参数呈现正相关(P0.01)。结论PCI导致的血管内皮损伤可以引发EPC时间依赖性的动态变化,同时可以促进CD34~+/KDR~+的大幅动员、迁移、归巢,有利于受损血管内皮修复愈合,减少并发症,改善患者预后。
[Abstract]:Objective to study the quantitative changes of circulating endothelial progenitor cells (EPC) in patients with chronic stable angina pectoris before and after percutaneous coronary intervention (PCI), and to explore the correlation between the maximum mobilization range of CD34 ~ / KDR~ after PCI and the quantitative parameters of endothelial injury.Methods Ninety-three patients with chronic stable angina pectoris were selected and 72 patients who were successfully treated with PCI were selected as the control group. 21 patients in the PCI group were treated conservatively by coronary angiography.The blood samples of the femoral artery sheath tube or the median elbow vein were collected, and the number of EPC was measured immediately after CAG in PCI group and control group (baseline level) and 24 h after PCI or 1 h after PCI or 5 h and 7 h after CAG by flow cytometry.Results there were significant differences in the total mean of different types of EPC at different time points and between the PCI group and the control group.涓庡熀绾挎按骞崇浉姣，

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