参附注射液治疗全心衰的临床疗效研究

发布时间：2018-05-09 00:05

本文选题：参附注射液 + 全心衰　；参考：《辽宁中医药大学》2017年硕士论文

【摘要】：目的:回顾性分析参附注射液结合常规西医治疗与单独应用常规西医治疗全心衰的患者临床效果,评价参附注射液联合西医治疗的疗效,进一步为治疗全心衰提供新的临床思路。材料与方法:1.临床资料:纳入2016年1月-2016年8月期间在辽宁省人民医院心脏中心临床诊断为全心衰住院患者共50例,研究组29例,对照组21例。2.研究组在常规心衰治疗基础上加用参附注射液80ml加入5%葡萄糖注射液100ml静脉滴注10天,对照组应用常规强心、利尿、扩血管等常规心衰治疗。比较治疗前与治疗后1个月后左室舒张末内径(LVEDD),左室射血分数,肺动脉压力;6分钟步行实验;N末端B型利钠肽(NT-pro BNP);心衰中医临床证候量化评分;西医心功能以及治疗过程中肝肾功损害等的不良反应,以评定临床治疗效果。结果:1.一般资料:两组数据一般资料无统计学差异(p0.05)。2.西医心功能评估:研究组可以明显改善患者心力衰竭症状(χ~2=6.948,p=0.0310.05)。3.中医临床证候分级量化积分及6分钟步行实验评价研究组有统计学意义(t=2.487,p=0.0170.05;χ~2=11.06,p=0.0090.05)。4.两组左室射血分数、左室舒张末内径、肺动脉高压、NT-pro BNP比较有统计学意义,显示结合参附注射液治疗会改善患者相关指标(t=3.249,p=0.000.05;t=5.898,p=0.0000.05;t=3.198,p=0.0030.05;t=2.827,p=0.0070.05)。5、未见明显不良反应。结论:1.参附注射液联合常规西医治疗可以改善全心衰患者的心功能,并可以有效改善患者心悸、乏力、气喘、恶心、浮肿等等中医证候。2.参附注射液联合常规西医治疗全心衰的疗效优于单纯应用西医常规治疗。3.未发生明显的药物不良反应,临床应用较为安全。
[Abstract]:Objective: to analyze retrospectively the clinical effect of Shenfu injection combined with conventional western medicine and conventional western medicine in treating total heart failure, and to evaluate the curative effect of Shenfu injection combined with western medicine. To further provide a new clinical thinking for the treatment of total heart failure. Materials and methods: 1. Clinical data: from January 2016 to August 2016, a total of 50 patients with total heart failure were diagnosed in the heart center of Liaoning Provincial people's Hospital, 29 patients in the study group and 21 cases in the control group. The study group was treated with Shenfu injection 80ml and 5% glucose injection 100ml for 10 days on the basis of routine heart failure treatment, while the control group was treated with routine heart failure, such as strengthening heart, diuretic and vasodilating. The left ventricular end-diastolic diameter (LVEDDG), left ventricular ejection fraction (LVEF), pulmonary artery pressure (PAP), N-terminal B-type natriuretic peptide (NT-pro BNPN) were compared before treatment and 1 month after treatment. In order to evaluate the clinical therapeutic effect, the adverse reactions of the heart function and the damage of liver and kidney in the course of treatment were evaluated. The result is 1: 1. General data: there was no statistical difference between the two groups of data. Evaluation of cardiac function in western medicine: the study group could obviously improve the symptoms of heart failure in patients (蠂 ~ (2 / 2) 6.948) 0.0310.05 ~ (.3). The quantitative score of clinical syndromes of TCM and the evaluation of 6-minute walking experiment in the study group had statistical significance (P 0.0170.05) and 蠂 ~ (2 +) (11.06) / (0.0090.05) ~ (.4). Left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEF) and NT-pro BNP were significantly different between the two groups. The results showed that treatment with Shenfu injection could improve the related indexes of patients. Conclusion 1. Shenfu injection combined with routine western medicine treatment can improve the heart function of patients with total heart failure, and can effectively improve palpitation, fatigue, asthma, nausea, swelling and other TCM syndromes. 2. The therapeutic effect of Shenfu injection combined with conventional western medicine on total heart failure is better than that of western medicine alone. No obvious adverse drug reactions occurred, and clinical application was relatively safe.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R541.6

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