阿卡波糖片对老年急性心肌梗死患者心室重构的影响

发布时间：2018-05-12 23:26

本文选题：老年 + 急性心肌梗死　；参考：《中国医学创新》2017年25期

【摘要】：目的:分析阿卡波糖片对老年急性心肌梗死患者心室重构的影响。方法:选取2014年10月-2016年10月本院收治的老年急性心肌梗死疾病患者92例作为研究对象,按照随机数字法分为对照组和治疗组,每组各46例。对照组采用常规抗心肌梗死用药方案,治疗组在对照组基础上加用阿卡波糖片。比较用药前后左心室射血分数、梗死面积、心房钠尿肽、TNF-α等相关指标水平的改善幅度、老年急性心肌梗死药物治疗总有效率、用药期间出现的心室重构例数、心肌功能恢复正常时间和用药总时间、药物不良反应率。结果:治疗组在用药前后左心室射血分数、梗死面积、心房钠尿肽、TNF-α等相关指标水平的改善幅度均显著高于对照组,比较差异均有统计学意义(P0.05);治疗组老年急性心肌梗死药物治疗总有效率为91.3%,高于对照组的71.7%,比较差异有统计学意义(P0.05);用药期间,治疗组心室重构出现3例,少于对照组的11例,比较差异有统计学意义(P0.05);心肌功能恢复正常时间和用药总时间均少于对照组,比较差异均有统计学意义(P0.05);治疗组药物不良反应率为4.3%,显著低于对照组的21.7%,比较差异有统计学意义(P0.05)。结论:老年急性心肌梗死疾病患者采用阿卡波糖片进行治疗,可以有效控制心室重构现象的发生,大幅度改善心肌功能,缩短用药时间。
[Abstract]:Objective: to analyze the effect of acarbose tablets on ventricular remodeling in elderly patients with acute myocardial infarction. Methods: 92 elderly patients with acute myocardial infarction (AMI) from October 2014 to October 2016 were randomly divided into control group (n = 46) and treatment group (n = 46). The control group was treated with routine anti-myocardial infarction regimen, and the treatment group was treated with acarbose tablets on the basis of the control group. The relative indexes such as left ventricular ejection fraction (LVEF), infarct area, atrial natriuretic peptide TNF- 伪, the total effective rate of drug therapy in elderly patients with acute myocardial infarction (AMI), and the number of cases of ventricular remodeling during medication were compared before and after treatment. The time of recovery of myocardial function, the total time of medication and the rate of adverse drug reaction. Results: the improvement of left ventricular ejection fraction, infarct area and atrial natriuretic peptide TNF- 伪 in the treatment group was significantly higher than that in the control group. The total effective rate of drug therapy for elderly patients with acute myocardial infarction in the treatment group was 91.3, which was higher than that in the control group (71.7), and the difference was statistically significant (P 0.05). During the treatment period, there were 3 cases of ventricular remodeling in the treatment group, less than 11 cases in the control group. The difference was statistically significant (P 0.05), the time of normal myocardial function and the total time of medication were less than those of the control group. The adverse drug reaction rate in the treatment group was 4.3which was significantly lower than that in the control group (21.7g), and the difference was statistically significant (P 0.05). Conclusion: the treatment of senile patients with acute myocardial infarction with acarbose tablets can effectively control the occurrence of ventricular remodeling, improve myocardial function and shorten the time of medication.
【作者单位】：云南省普洱市人民医院;
【分类号】：R542.22

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