基于文献计量学心肌梗死模型大鼠血清代谢组学的特点

发布时间：2018-06-08 12:52

本文选题：心肌梗死 + 代谢组学　；参考：《中国组织工程研究》2017年04期

【摘要】：背景:研究证实,代谢组学可以从一个总体轮廓上对大鼠心肌梗死病理代谢产物进行分析,从全面总体的角度对大鼠心肌梗死机制进行观察。目的:进一步分析大鼠心肌梗死模型血清代谢组生物信息学通路。方法:从中国知网、万方数据库、维普数据库、Embase、PubM ed数据库中检索大鼠心肌梗死的实验研究。对纳入研究代谢产物进行汇总。信号通路分析采用KEGG,代谢产物分子注释、相关的酶或转运蛋白及其相关性质分析采用HMDB,代谢产物路径可视化采用metP A网络软件。结果与结论:(1)共有10篇文献纳入分析,有26个代谢产物在这些文献中重复出现,主要参与了29条代谢路径;(2)通过通路拓扑分析选出了5条代谢通路作为大鼠心肌梗死代谢通路,分别是:氨酰tR NA生物合成、甘氨酸、丝氨酸和苏氨酸代谢、缬氨酸、亮氨酸和异亮氨酸的生物合成、不饱和脂肪酸的生物合成、苯丙氨酸,酪氨酸和色氨酸生物合成;(3)大鼠心肌梗死代谢组生物信息分析显示心肌梗死发病机制涉及到糖类、脂肪、蛋白质、RNA等物质代谢及其代谢通路。
[Abstract]:Background: studies have confirmed that metabolomics can be used to analyze the pathological metabolites of myocardial infarction in rats from a global profile and to observe the mechanism of myocardial infarction in rats from a comprehensive perspective. Objective: to further analyze the bioinformatics pathway of serum metabolism group in rat myocardial infarction model. Methods: an experimental study of myocardial infarction in rats was carried out from the databases of China Zhiwang, Wanfang, Weipu, Embase and PubMed. The metabolites included in the study were summarized. The signal pathway was analyzed by KEGG, the metabolites were annotated, the related enzymes or transporters and their related properties were analyzed by HMDB.MetP A network software was used to visualize the pathway of metabolites. Results and conclusion A total of 10 articles were included in the analysis. 26 metabolites were repeated in these literatures, mainly involved in 29 metabolic pathways. 5 metabolic pathways were selected as metabolic pathways of myocardial infarction in rats by topological analysis of the pathways. They are: biosynthesis of amino acid tr na, metabolism of glycine, serine and threonine, biosynthesis of valine, leucine and isoleucine, biosynthesis of unsaturated fatty acids, phenylalanine, phenylalanine, Tyrosine and Tryptophan biosynthesis: bioinformatics analysis of metabolic group showed that the pathogenesis of myocardial infarction was related to the metabolism of carbohydrate, fat, protein and RNA and its metabolic pathway.
【作者单位】：广西中医药大学研究生院;广西中医药大学附属瑞康医院心血管内科;
【基金】：国家自然科学基金(81360535) 广西科学研究与技术开发计划项目(桂科攻1598012-55) 广西壮族自治区教育厅,广西高等学校优秀中青年骨干教师培养工程资助(桂教人[2013]16号)~~
【分类号】：R542.22

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