女性体检人群持续焦虑和（或）抑郁状态与动脉硬化的相关性分析

发布时间：2018-07-21 13:14

【摘要】：目的:初步了解目标群体中动脉硬化的患病率,研究女性体检人群持续焦虑和(或)抑郁状态与动脉硬化的相关性。方法:选取2016年1月至2016年10月来我院体检的女性人群,进行详细的问卷调查、体格检查、血生化指标测定,共纳入符合标准的体检者216例,进行焦虑抑郁评分以及臂踝脉搏波传导速度(baPWV)和踝臂指数(ABI)检测,用baPWV和(或)ABI异常作为动脉硬化的替代指标,baPWV和(或)ABI异常者共74例,划入观察组,baPWV和ABI均正常者142例,划入对照组,采用多因素非条件Logistic回归来分析女性体检人群持续焦虑和(或)抑郁状态与动脉硬化的相关性。结果:两组体检者的年龄、静息心率、收缩压、舒张压、持续焦虑和(或)抑郁状态患病率差异有统计学意义(P0.05),Logistic回归分析显示年龄、静息心率、收缩压、舒张压、持续焦虑和(或)抑郁状态是动脉硬化的影响因素,其OR值分别为2.734(95%CI:2.216~3.363),2.378(95%CI:1.609~3.442),3.165(95%:为2.544~4.097),1.540(95%CI:1.059~2.063),1.902(95%CI:1.352~2.571),在校正了年龄、静息心率、收缩压、舒张压等因素后,持续焦虑和(或)抑郁状态仍与动脉硬化相关,其OR值为1.485(95%CI:1.052~1.973)。结论:1.在控制了血糖、血脂、体质指数、吸烟、血同型半胱氨酸、血尿酸等传统心血管危险因素后,年龄、静息心率、收缩压、舒张压、持续焦虑和(或)抑郁状态是女性体检人群动脉硬化的危险因素。2.女性体检人群持续焦虑和(或)抑郁状态与动脉硬化独立正相关。
[Abstract]:Objective: to investigate the prevalence of arteriosclerosis in the target population and to study the relationship between persistent anxiety and / or depression and arteriosclerosis. Methods: from January 2016 to October 2016, a total of 216 women who met the standard of physical examination were enrolled in the study. Anxiety and depression scores, brachial pulse wave velocity (baPWV) and ankle brachial index (ABI) were measured in 74 patients with abnormal BAPWV and / or ABI as a substitute for arteriosclerosis, and 142 patients with normal BAPWV and ABI in the observation group. In the control group, multivariate conditional logistic regression was used to analyze the relationship between persistent anxiety and / or depression and arteriosclerosis. Results: there were significant differences in age, resting heart rate, systolic blood pressure, diastolic blood pressure, persistent anxiety and / or depression between the two groups (P0.05) logistic regression analysis showed that age, resting heart rate, systolic blood pressure, diastolic blood pressure were significantly different between the two groups. Persistent anxiety and / or depression are influential factors in atherosclerosis, with OR values of 2.734 (95 CI: 2.2163.363) 2.378 (95CI: 1.609 3.442) 3.165 (95: 2.5444.097) 1.902 (95CI: 1.0592.063) 1.902 (95CI: 1.3522.571). After adjusting for age, resting heart rate, systolic pressure, diastolic pressure and other factors, persistent anxiety and (or) depression are still associated with atherosclerosis. Its OR value is 1.485 (95 CI: 1.052 / 1.973). Conclusion 1. After controlling for traditional cardiovascular risk factors such as blood glucose, blood lipids, body mass index, smoking, homocysteine, uric acid, age, resting heart rate, systolic blood pressure, diastolic blood pressure, Persistent anxiety and / or depression are risk factors of arteriosclerosis. Persistent anxiety and / or depression were positively correlated with atherosclerosis.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R543.5

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