miRNAs and lncRNAs in vascular injury and remodeling

  本文关键词：miRNAs and lncRNAs in vascular injury and remodeling，，由笔耕文化传播整理发布。

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SCIENCE CHINA-LIFE SCIENCES, 2014; 57 (8): 826

Song, XW; Shan, DK; Chen, J; Jing, Q

Jing, Q (reprint author), Changhai Hosp, Dept Cardiol, Shanghai 200433, Peoples R China.

Abstract
Vascular injury, remodeling, as well as angiogenesis, are the leading causes of coronary or cerebrovascular disease. The blood vessel functional imbalance trends to induce atherosclerosis, hypertension, and pulmonary arterial hypertension. As several genes have been identified to be dynamically regulated during vascular injury and remodeling, it is becoming widely accepted that several types of non-coding RNA, such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), are involved in regulating the endothelial cell and vascular smooth muscle cell (VSMC) behaviors. Here, we review the progress of the extant studies on mechanistic, clinical and diagnostic implications of miRNAs and lncRNAs in vascular injury and remodeling, as well as angiogenesis, emphasizing the important roles of miRNAs and lncRNAs in vascular diseases. Furthermore, we introduce the interaction between miRNAs and lncRNAs, and highlight the mechanism through which lncRNAs are regulating the miRNA function. We envisage that continuous in-depth research of non-coding RNAs in vascular disease will have significant implications for the treatment of coronary or cerebrovascular diseases.

SCIENCE CHINA-LIFE SCIENCES 影响因子：2.297    (投稿经验 | MedSci指数 | 杂志信息 )
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  本文关键词：miRNAs and lncRNAs in vascular injury and remodeling，由笔耕文化传播整理发布。