谷氨酰基转肽酶与血尿酸在冠心病中的交互作用

发布时间：2018-08-31 08:57

【摘要】：目的探讨谷氨酰基转肽酶、血尿酸与冠心病的关系及其交互作用。方法病例组选取2010年8月至2011年6月在延边大学附属医院心内科的冠心病患者172例,对照组选取延边大学附属医院体检科参与体检的无冠心病及高血压者203例。测定研究对象的总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、空腹血糖(FPG)、谷草转氨酶(AST)、谷丙转氨酶(ALT)、γ-谷氨酰转移酶(GGT)、总胆红素(TBIL)、间接胆红素(DBIL)、尿酸(UA),比较分析冠心病组和对照组的GGT和UA水平。结果冠心病患者中GGT和UA水平均高于对照组。高UA组及GGT第三分位组患冠心病的危险分别是正常尿酸组和GGT第一分位组的2.847倍和2.889倍,调整年龄、性别、收缩压(SBP)、舒张压(DBP)、TC、TG、LDL、HDL、FPG、UA后分别为2.358倍和2.667倍。高UA组且GGT第三分位组患冠心病的危险是正常尿酸且GGT第一分位组的5.461倍,调整年龄、性别、SBP、DBP、TC、TG、LDL、HDL、FPG后4.121倍。结论血清GGT和UA与冠心病之间存在相关性。
[Abstract]:Objective to investigate the relationship and interaction between glutamyl transpeptidase, uric acid and coronary heart disease. Methods from August 2010 to June 2011, 172 patients with coronary heart disease (CHD) in the Department of Cardiology, affiliated Hospital of Yanbian University, and 203 patients without coronary heart disease (CHD) and hypertension who participated in physical examination in the Department of physical examination of affiliated Hospital of Yanbian University were selected as the control group. Total cholesterol, (TC), triglyceride, (TG), high density lipoprotein, (HDL), low density lipoprotein, (LDL), fasting blood glucose, (FPG), glutamic oxaloacetic transaminase, (AST), alanine aminotransferase, (ALT), 纬 -glutamyl transferase, (GGT), total bilirubin, (TBIL), indirect bilirubin (DBIL), (UA), ratio The levels of GGT and UA were compared between coronary heart disease group and control group. Results the levels of GGT and UA in patients with coronary heart disease were higher than those in control group. The risk of coronary heart disease in the high UA group and the third position GGT group was 2.847 and 2.889 times higher than that in the normal uric acid group and the GGT first position group, respectively. The age, sex and systolic (SBP), diastolic blood pressure (DBP) were 2.358 and 2.667 times higher than those in the control group. The risk of coronary heart disease in the high UA group and the third position GGT group was 5.461 times higher than that in the normal uric acid group and the first position group of GGT. Conclusion there is a correlation between serum GGT and UA and coronary heart disease.
【作者单位】：延边大学医学院预防医学教研室;延边大学附属医院心血管内科;
【分类号】：R541.4

【相似文献】