红细胞分布宽度对阵发性房颤患者合并左心室肥厚临床研究

发布时间：2018-09-08 13:33

【摘要】：背景：左心室肥厚(LVH)是心血管并发症的重要危险因素,以往的研究显示,红细胞分布宽度(RDW)与心血管疾病的发生率和死亡率有关,然而,很少有研究探讨RDW与LVH之间的相关性,本研究的目的就是探讨阵发性房颤患者RDW水平与左心室肥厚之间的关系。方法：收集了87例经南昌大学第一附属医院诊断为阵发性房颤的患者进行实验室及超声心动图检查,采用Logistic回归分析来证实RDW是阵发性房颤患者左心室肥厚的独立预测因子。结果：本研究纳入了29例阵发性房颤合并左心室肥厚及58例未合并左心室肥厚的患者,LVH组与非LVH组相比RDW、SBP、IVST、LVPWT、LAD、LVMI明显升高,而LVEF则显著下降,Logistic多元回归分析表明,RDW是阵发性房颤患者LVH的独立预测因子(OR=5.806,95% CI:1.798-18.748,P0.05),SBP和FBG也是左心室肥厚的预测因子。绘制受试者工作曲线(Receiver Operating Characteristic,ROC)计算曲线下的面积为0.785(95%CI 0.6879 to 0.8816,P0.05), RDW最佳截断值为12.95,此时RDW预测阵发性房颤患者LVH的灵敏度和特异度分别为82.76%和62.07%。结论：RDW水平在LVH组明显升高,与阵发性房颤合并左心室肥厚有关,RDW可能成为阵发性房颤患者左心室肥厚的一个预测指标。
[Abstract]:Background: left ventricular hypertrophy (LVH) is an important risk factor for cardiovascular complications. Previous studies have shown that RBC distribution width (RDW) is associated with the incidence and mortality of cardiovascular disease. However, few studies have explored the correlation between RDW and LVH. The aim of this study was to investigate the relationship between RDW levels and left ventricular hypertrophy in patients with paroxysmal atrial fibrillation. Methods: 87 patients with paroxysmal atrial fibrillation diagnosed by the first affiliated Hospital of Nanchang University were examined by laboratory and echocardiography. Logistic regression analysis was used to confirm that RDW was an independent predictor of left ventricular hypertrophy in patients with paroxysmal atrial fibrillation. Results: in this study, 29 patients with paroxysmal atrial fibrillation with left ventricular hypertrophy and 58 patients with no left ventricular hypertrophy were enrolled in this study. The RDW,SBP,IVST,LVPWT,LAD,LVMI was significantly increased in patients with paroxysmal atrial fibrillation associated with left ventricular hypertrophy compared with non-LVH group. Logistic multiple regression analysis showed that LVEF was an independent predictor of LVH in paroxysmal atrial fibrillation (PAF). SBP and FBG were also predictors of left ventricular hypertrophy. The area under the curve was 0.785 (95%CI 0.6879 to 0.8816), RDW). The best truncation value of RDW was 12.95. The sensitivity and specificity of RDW in predicting LVH in patients with paroxysmal atrial fibrillation were 82.76% and 62.07%, respectively. Conclusion the level of RDW in LVH group was significantly higher than that in control group. RDW may be a predictor of left ventricular hypertrophy in patients with paroxysmal atrial fibrillation associated with left ventricular hypertrophy.
【学位授予单位】：南昌大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R541.75

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