射频消融术联合氟哌噻吨美利曲辛对快速心律失常患者的治疗效果观察

发布时间：2018-10-23 18:24

【摘要】：目的探讨射频消融术联合氟哌噻吨美利曲辛对快速心律失常患者的治疗效果。方法选取快速心律失常患者98例,随机分为射频组和联合组各49例。两组进行射频消融术治疗,联合组在此基础上口服氟哌噻吨美利曲辛片,疗程均为2周。分别于术前及术后2天、2周时进行汉密尔顿焦虑量表(HAMA)和汉密尔顿抑郁量表(HAMD)评分,检测左室舒张末期内径(LVEDD)、左室射血分数(LVEF)、每搏量(SV)、心脏指数(CI)、舒张早期最大血液流速与舒张晚期最大血液流速比值(E/A);分别于术前及术后2周时采用SCL-90量表评价生活质量;术后2周时统计临床疗效及不良反应。结果术后2天及2周,两组LVEDD均较术前降低,LVEF、SV、CI、E/A均较术前升高(P均0.01);术后2周,联合组LVEDD低于射频组,LVEF、SV、CI、E/A均高于射频组(P均0.01)。术后2周时两组SCL-90量表各项目评分均较术前降低(P均0.01),且联合组均低于射频组(P均0.01)。术后2周时联合组HAMA和HAMD评分均较术前及术后2天降低,且均低于射频组同期水平(P均0.01)。术后2周时射频组总有效率低于联合组(P0.05);射频组并发症发生率为4.08%,联合组为8.16%,组间比较P0.05。结论射频消融术联合氟哌噻吨美利曲辛可明显改善快速心律失常患者焦虑、抑郁状态,提高其心功能和生活质量。
[Abstract]:Objective to investigate the therapeutic effect of radiofrequency ablation combined with droperazothioate melitaxine in patients with tachyarrhythmia. Methods 98 patients with tachyarrhythmia were randomly divided into radio frequency group (n = 49) and combined group (n = 49). Radiofrequency ablation was performed in both groups, and the combined group was treated with fluoperazidone metriaxine tablets for 2 weeks. Hamilton anxiety scale (HAMA) and Hamilton Depression scale (HAMD) were evaluated before and 2 days after operation. Left ventricular end-diastolic diameter (LVEDD), left ventricular ejection fraction (LVEF), (SV), cardiac index (SV), early diastolic maximum blood velocity (CI),) and late diastolic maximum blood velocity (E / A) were measured, and the quality of life (QOL) was evaluated by SCL-90 scale before and 2 weeks after operation. The clinical efficacy and adverse reactions were analyzed 2 weeks after operation. Results on the 2nd day and 2nd week after operation, the LVEDD of the two groups was lower than that of the preoperative group, and the LVEF,SV,CI,E/A of the combined group was higher than that of the preoperative group (P0.01), and the LVEDD of the combined group was lower than that of the radiofrequency group and the LVEF,SV,CI,E/A of the combined group was higher than that of the radiofrequency group 2 weeks after operation (all P 0.01). At 2 weeks after operation, the scores of SCL-90 in both groups were lower than those before operation (P0.01), and the scores in the combined group were lower than those in the radiofrequency group (P0.01). The scores of HAMA and HAMD in the combined group were lower than those before and 2 days after operation, and were lower than those in the radiofrequency group at 2 weeks after operation (P0.01). At 2 weeks after operation, the total effective rate of radiofrequency group was lower than that of the combined group (P0.05), the incidence of complications in the radiofrequency group was 4.08 and 8.16 in the combined group, and there was a comparison between the two groups (P0.05). Conclusion radiofrequency ablation combined with droperazothioate metroxine can significantly improve anxiety and depression in patients with tachyarrhythmia and improve cardiac function and quality of life of patients with tachyarrhythmia.
【作者单位】：安徽省第二人民医院;中国人民解放军第88医院;
【分类号】：R541.7

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