尿液巯基化合物检测在筛查子宫颈癌及癌前病变中的临床价值

发布时间：2018-10-25 13:56

【摘要】：目的 探讨尿液巯基化合物检测作为子宫颈癌早期筛查手段的可行性。方法 收集144例就诊者尿液作为对照组,其中包括健康体检结果正常人员104例、阴道炎患者20例、人乳头瘤病毒(HPV)感染者20例;确诊子宫颈癌等妇科肿瘤患者的尿液标本107例作为研究组。取1 m L新鲜尿液作为标本,使用化学显色法对标本进行巯基化合物含量检测,并以宫颈活检的组织病理学为金标准,评价尿液中巯基含量检测在子宫颈癌筛查中的临床价值。结果 在研究组中阳性反应有98例,阳性率为91.6%;健康对照组中人员无阳性反应;阴道炎患者阳性反应有5例,阳性率为25%;HPV感染者阳性反应有12例,阳性率为60%;研究组与健康对照组之间尿液巯基检测阳性率差异有统计学意义(P0.01)。结论 尿液中巯基化合物检测对子宫颈癌及癌前病变筛查具有较高的敏感度,该方法简便、快速,适用于子宫颈癌的早期筛查。
[Abstract]:Objective to investigate the feasibility of urine thiol compound detection as an early screening method for cervical cancer. Methods 144 cases of urine were collected as control group, including 104 normal subjects, 20 patients with vaginitis and 20 patients with human papillomavirus (HPV) infection. Urine samples from 107 patients with cervical cancer and other gynecologic tumors were used as the study group. Using 1 mL fresh urine as a specimen, the content of sulfhydryl compounds was detected by chemical colorimetry, and the clinical value of the detection of thiol in urine in cervical cancer screening was evaluated with the histopathology of cervical biopsy as the gold standard. Results in the study group, 98 cases were positive, the positive rate was 91.6; in the healthy control group, there was no positive reaction; in vaginitis, there were 5 cases of positive reaction, and the positive rate was 25 cases of HPV infection in 12 cases. The positive rate was 60. There was significant difference between the study group and the healthy control group (P0.01). Conclusion the detection of sulfhydryl compounds in urine is sensitive to the screening of cervical cancer and precancerous lesions. This method is simple, rapid and suitable for early screening of cervical cancer.
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