miRNA-145对血管平滑肌细胞功能调节与心血管疾病研究进展

发布时间：2018-12-07 17:56

【摘要】：血管平滑肌细胞(vascular smooth muscle cell,VSMC)是血管壁主要细胞类型,在维持血管正常生理功能过程扮演重要角色,其在正常环境下是一种具有调节血管壁张力、维持血压等功能的高度分化型细胞(收缩型)。在血管增殖性疾病的发展过程中,VSMC由分化型转化为具有合成和分泌多种基质蛋白能力的未分化型(合成型),导致自身肥大、血管内膜增厚、血管狭窄等病理结果,这些是形成高血压、动脉粥样硬化等血管增殖性疾病的病理基础。近年来发现miRNAs参与心血管生理、病理过程的调控并且与VSMC密切相关,其中miR-145经证实是正常动脉壁表达最为丰富的micoRNAs,其在VSMC功能调节中起着非常重要的作用,这可能为治疗高血压、动脉粥样硬化等血管增殖性疾病提供新的诊断、治疗依据。本文就miR-145对VSMC功能调节以及心血管疾病病理生理学意义作一综述。
[Abstract]:Vascular smooth muscle cell (vascular smooth muscle cell,VSMC) is the main cell type of vascular wall, which plays an important role in maintaining the normal physiological function of blood vessel. Highly differentiated (contractile) cells that maintain functions such as blood pressure. During the development of vascular proliferative disease, VSMC changes from differentiation type to undifferentiated type (synthetic type) with the ability to synthesize and secrete many kinds of matrix proteins, which results in hypertrophy, thickening of vascular intima, stenosis of blood vessel and so on. These are the pathological basis for vascular proliferative diseases such as hypertension and atherosclerosis. In recent years, it has been found that miRNAs is involved in the regulation of cardiovascular physiology and pathological process and is closely related to VSMC. MiR-145 has been proved to be the most expressed micoRNAs, in normal arterial wall, which plays a very important role in the regulation of VSMC function. This may provide a new diagnosis and treatment basis for vascular proliferative diseases such as hypertension and atherosclerosis. This article reviews the role of miR-145 in the regulation of VSMC function and the pathophysiology of cardiovascular disease.
【作者单位】：广西医科大学药学院;
【分类号】：R54

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