不同破口位置对主动脉夹层真假腔内压力及肾肠灌注的影响

发布时间：2018-12-07 18:53

【摘要】：为提高主动脉夹层疾病的治疗效果,针对主动脉夹层疾病,研究主动脉夹层内的血流动力学变化,尤其是不同破口位置下,夹层患者的肾肠等器官的灌注情况及产生的影响.利用3D打印技术制作不同破口位置的主动脉夹层模型,通过实验方法进行主动脉夹层内血流模拟,并对主动脉夹层模型真假腔内的压力及肾肠支脉的压力进行测量,辅以超声技术进行观测.不同破口位置下,真假腔压力都会随不同基准压力(15 960、21 280、26 600 Pa)的升高而增大,在3种基准压力水平(15 960、21 280、26 600 Pa)下,模型B肠系膜动脉压力明显高于模型A肠系膜动脉压力.真假腔压力会随不同基准压力的升高而增大,压力极差变化更加剧烈,管壁的负担加重,夹层破裂风险更大.降压手段支持下,模型B有可能出现肠器官灌注不良状态,即因低灌出现脏器缺血情况.
[Abstract]:In order to improve the therapeutic effect of aortic dissection disease, the hemodynamic changes in aortic dissection were studied, especially the perfusion of renal and intestinal organs in dissection patients. The 3D printing technique was used to make the aortic dissection model with different opening positions. The blood flow in the aortic dissection was simulated by the experimental method. The pressure in the true and false lumen of the aortic dissection model and the pressure of the renal and intestinal branches were measured. It was observed by ultrasonic technique. The true and false cavity pressure will increase with the increase of different reference pressure (15 960N 21 280 ~ 26 600 Pa) at different opening positions, and at three kinds of reference pressure levels (15 960N 21 280 ~ 26 600 Pa), the cavity pressure will increase with the increase of different reference pressure (15 960U 21 280? 26 600 Pa). The pressure of mesenteric artery in model B was significantly higher than that in model A. The true and false cavity pressure will increase with the increase of different datum pressure, the pressure difference will change more sharply, the burden of pipe wall will increase, and the risk of interlayer rupture will be greater. Under the support of hypotension, intestinal organ perfusion may occur in model B, that is, visceral ischemia due to low perfusion.
【作者单位】：北京工业大学生命科学与生物工程学院;首都医科大学附属北京安贞医院;
【分类号】：R318.01

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