RyR2磷酸化在心力衰竭中的作用
发布时间：2019-02-18 19:42
【摘要】：心力衰竭在细胞水平主要表现为心肌以兴奋-收缩耦联(excitement-contraction coupling,ECC)为基础的收缩功能障碍,而Ca2+信号转导在此过程中起着非常重要的作用。肌浆网(sarcoplasmic reticulum,SR)兰尼碱受体(ryanodine receptor type 2,RyR2)是心肌最重要的钙释放通道,RyR2磷酸化是肌浆网钙释放的基础,而RyR2磷酸化主要受蛋白激酶A(protein kinase A,PKA)和钙离子/钙调蛋白依赖性蛋白激酶Ⅱ(calcium/calmodulin dependent protein kinaseⅡ,CaMKⅡ)的调控。目前对RyR2磷酸化的研究已经非常广泛,但对其涉及心力衰竭的具体发病机制仍有争议,本综述主要针此问题进行阐述。
[Abstract]:Heart failure is characterized by contraction dysfunction based on excitation-contraction coupling (excitement-contraction coupling,ECC) at cellular level, and Ca2 signal transduction plays a very important role in this process. Sarcoplasmic reticulum (sarcoplasmic reticulum,SR) (ryanodine receptor type _ 2 (ryanodine receptor type _ 2 RyR2 is the most important calcium release channel in myocardium. RyR2 phosphorylation is the basis of sarcoplasmic reticulum calcium release, while RyR2 phosphorylation is mainly caused by protein kinase A (protein kinase A,. PKA and calcium/calmodulin dependent protein kinase 鈪，
本文编号：2426141
[Abstract]:Heart failure is characterized by contraction dysfunction based on excitation-contraction coupling (excitement-contraction coupling,ECC) at cellular level, and Ca2 signal transduction plays a very important role in this process. Sarcoplasmic reticulum (sarcoplasmic reticulum,SR) (ryanodine receptor type _ 2 (ryanodine receptor type _ 2 RyR2 is the most important calcium release channel in myocardium. RyR2 phosphorylation is the basis of sarcoplasmic reticulum calcium release, while RyR2 phosphorylation is mainly caused by protein kinase A (protein kinase A,. PKA and calcium/calmodulin dependent protein kinase 鈪，
本文编号：2426141
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